Adenomatosis Polyposis Coli Protein (APC)

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DP2; DP2.5; DP3; FAP; FPC; GS; Deleted in polyposis 2.5

Adenomatosis Polyposis Coli Protein (APC)
APC (adenomatosis polyposis coli) is classified as a tumor suppressor gene. Tumor suppressor genes prevent the uncontrolled growth of cells that may result in cancerous tumors. The protein made by the APC gene plays a critical role in several cellular processes that determine whether a cell may develop into a tumor. The APC protein helps control how often a cell divides, how it attaches to other cells within a tissue, or whether a cell moves within or away from a tissue. This protein also helps ensure that the chromosome number in cells produced through cell division is correct. The APC protein accomplishes these tasks mainly through association with other proteins, especially those that are involved in cell attachment and signaling. The activity of one protein in particular, beta-catenin, is controlled by the APC protein.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC314Hu01Recombinant Adenomatosis Polyposis Coli Protein (APC)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC314Hu01Polyclonal Antibody to Adenomatosis Polyposis Coli Protein (APC)WB, ICC, IHC-P, IHC-F, ELISA
MAC314Hu22Monoclonal Antibody to Adenomatosis Polyposis Coli Protein (APC)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC314HuELISA Kit for Adenomatosis Polyposis Coli Protein (APC)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC314Mu01Recombinant Adenomatosis Polyposis Coli Protein (APC)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC314Mu01Polyclonal Antibody to Adenomatosis Polyposis Coli Protein (APC)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC314MuELISA Kit for Adenomatosis Polyposis Coli Protein (APC)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC314Ra01Recombinant Adenomatosis Polyposis Coli Protein (APC)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC314Ra01Polyclonal Antibody to Adenomatosis Polyposis Coli Protein (APC)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Adenomatosis Polyposis Coli Protein (APC)CLIA Kit Customized Service Offer
n/aELISA Kit for Adenomatosis Polyposis Coli Protein (APC)ELISA Kit Customized Service Offer
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  43. ErratumHum. Mol. Genet. 3:1918-1918(1994)
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  48. "The APC I1307K allele and breast cancer risk." Nat. Genet. 20:13-14(1998) [PubMed] [Europe PMC] [Abstract]
  49. "The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history."Proc. Natl. Acad. Sci. U.S.A. 95:10722-10727(1998) [PubMed] [Europe PMC] [Abstract]
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  51. "Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism."Am. J. Hum. Genet. 64:378-384(1999) [PubMed] [Europe PMC] [Abstract]
  52. "Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition."J. Med. Genet. 36:14-20(1999) [PubMed] [Europe PMC] [Abstract]
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