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Bcl2 Associated Death Promoter (BAD)

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BBC2; BCL2L8; BCL2-Antagonist Of Cell Death; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death

Bcl2 Associated Death Promoter (BAD)
CCC C337
HGNC 936
MGI 1096330
PubMed 21130780
RGD 620103
UniProt Q92934
Wiki BAD

The Bcl-2-associated death promoter (BAD) protein is a pro-apoptotic member of the Bcl-2 gene family which is involved in initiating apoptosis. It does not contain a C-terminal transmembrane domain for outer mitochondrial membrane and nuclear envelope targeting, unlike most other members of the Bcl-2 family . After activation, it is able to form a heterodimer with anti-apoptotic proteins and prevent them from stopping apoptosis. The Bcl-2-associated death promoter (BAD) protein is a member of the Bcl-2 gene family. Some members of this family are pro-apoptotic (e.g., Bax, Bak) while others are anti-apoptotic (e.g., Bcl-2, Bcl-xL). Bax/Bak are believed to initiate apoptosis by forming a pore in the mitochondrial outer membrane that allows cytochrome c to escape into the cytoplasm and activate the pro-apoptotic caspase cascade.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC337Hu01 Recombinant Bcl2 Associated Death Promoter (BAD) Positive Control; Immunogen; SDS-PAGE; WB.
RPC337Hu04 Recombinant Bcl2 Associated Death Promoter (BAD) Positive Control; Immunogen; SDS-PAGE; WB.
RPC337Hu02 Recombinant Bcl2 Associated Death Promoter (BAD) Positive Control; Immunogen; SDS-PAGE; WB.
RPC337Hu03 Recombinant Bcl2 Associated Death Promoter (BAD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC337Hu01 Polyclonal Antibody to Bcl2 Associated Death Promoter (BAD) WB; IHC; ICC; IP.
Assay Kits SEC337Hu ELISA Kit for Bcl2 Associated Death Promoter (BAD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bcl2 Associated Death Promoter (BAD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bcl2 Associated Death Promoter (BAD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bcl2 Associated Death Promoter (BAD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bcl2 Associated Death Promoter (BAD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Associated Death Promoter (BAD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bcl2 Associated Death Promoter (BAD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bcl2 Associated Death Promoter (BAD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bcl2 Associated Death Promoter (BAD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bcl2 Associated Death Promoter (BAD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Associated Death Promoter (BAD) ELISA Kit Customized Service Offer
  1. "Bcl-2 targets the protein kinase Raf-1 to mitochondria."Cell 87:629-638(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins."J. Biol. Chem. 272:30866-30872(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage."J. Biol. Chem. 275:34451-34458(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis."J. Biol. Chem. 276:14414-14419(2001) [PubMed] [Europe PMC] [Abstract]
  8. "p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD."Mol. Cell. Biol. 23:5526-5539(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines."Cancer Res. 66:6741-6747(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis."Cancer Sci. 98:321-328(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt."Proc. Natl. Acad. Sci. U.S.A. 108:6085-6090(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies."Protein Sci. 9:2528-2534(2000) [PubMed] [Europe PMC] [Abstract]