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Bcl2 Interacting Killer, Apoptosis Inducing (BIK)

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BIP1; BP4; NBK; Apoptosis inducer NBK

Bcl2 Interacting Killer, Apoptosis Inducing (BIK)
CCC C338
HGNC 1051
MGI 1206591
PubMed 19632297
RGD 621547
UniProt Q13323
Wiki BIK

Bcl-2-interacting killer is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.

This death-promoting activity of BIK was suppressed by coexpression of BCL2, BCLXL, EBV BHRF1, and E1B 19-kD, suggesting that BIK may be a common target for antiapoptotic proteins. The predicted 160-amino acid BIK protein contains a C-terminal hydrophobic domain, a characteristic shared by BCL2 family members.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bcl2 Interacting Killer, Apoptosis Inducing (BIK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bcl2 Interacting Killer, Apoptosis Inducing (BIK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bcl2 Interacting Killer, Apoptosis Inducing (BIK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bcl2 Interacting Killer, Apoptosis Inducing (BIK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Interacting Killer, Apoptosis Inducing (BIK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bcl2 Interacting Killer, Apoptosis Inducing (BIK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bcl2 Interacting Killer, Apoptosis Inducing (BIK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bcl2 Interacting Killer, Apoptosis Inducing (BIK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bcl2 Interacting Killer, Apoptosis Inducing (BIK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Interacting Killer, Apoptosis Inducing (BIK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bcl2 Interacting Killer, Apoptosis Inducing (BIK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bcl2 Interacting Killer, Apoptosis Inducing (BIK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bcl2 Interacting Killer, Apoptosis Inducing (BIK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bcl2 Interacting Killer, Apoptosis Inducing (BIK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Interacting Killer, Apoptosis Inducing (BIK) ELISA Kit Customized Service Offer
  1. "Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins."Oncogene 11:1921-1928(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K."Mol. Cell. Biol. 16:5857-5864(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer."Gastroenterology 117:831-837(1999) [PubMed] [Europe PMC] [Abstract]
  4. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions."EMBO J. 14:5589-5596(1995) [PubMed] [Europe PMC] [Abstract]
  8. "A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis."Cell. Mol. Life Sci. 65:3822-3829(2008) [PubMed] [Europe PMC] [Abstract]