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Chibby Homolog 1 (CBY1)

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CBY; PGEA1; PIGEA14; arb1; Chibby; PKD2 Interactor,Golgi And Endoplasmic reticulum Associated 1; ARPP-binding protein; Cytosolic leucine-rich protein

Chibby Homolog 1 (CBY1)
CCC C364
HGNC 1307
MGI 1920989
PubMed 19838061
RGD 708481
UniProt Q9Y3M2
Wiki CBY1

Protein chibby homolog 1 is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC364Hu01 Recombinant Chibby Homolog 1 (CBY1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC364Hu01 Polyclonal Antibody to Chibby Homolog 1 (CBY1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Chibby Homolog 1 (CBY1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chibby Homolog 1 (CBY1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC364Mu01 Recombinant Chibby Homolog 1 (CBY1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC364Mu01 Polyclonal Antibody to Chibby Homolog 1 (CBY1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Chibby Homolog 1 (CBY1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chibby Homolog 1 (CBY1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chibby Homolog 1 (CBY1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chibby Homolog 1 (CBY1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chibby Homolog 1 (CBY1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chibby Homolog 1 (CBY1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chibby Homolog 1 (CBY1) ELISA Kit Customized Service Offer
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  7. "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway."Nature 422:905-909(2003) [PubMed] [Europe PMC] [Abstract]
  8. "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2."J. Biol. Chem. 279:35009-35016(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]