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Claudin 1 (CLDN1)

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CLD1; ILVASC; SEMP1; Senescence-Associated Epithelial Membrane Protein 1

Claudin 1 (CLDN1)
CCC C388
HGNC 2032
MGI 1276109
PubMed 10669103
RGD 68422
UniProt O95832
Wiki CLDN1

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands.

Claudin-1 is a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC388Hu01 Recombinant Claudin 1 (CLDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC388Hu01 Polyclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IP.
MAC388Hu22 Monoclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IP.
Assay Kits SEC388Hu ELISA Kit for Claudin 1 (CLDN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Claudin 1 (CLDN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Claudin 1 (CLDN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Claudin 1 (CLDN1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC388Mu ELISA Kit for Claudin 1 (CLDN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC388Ra01 Recombinant Claudin 1 (CLDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC388Ra01 Polyclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IP.
MAC388Ra21 Monoclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IP.
Assay Kits SEC388Ra ELISA Kit for Claudin 1 (CLDN1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily."Gene 226:285-295(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids."Cytogenet. Cell Genet. 88:217-217(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer."Hum. Genet. 107:249-256(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease."Gastroenterology 127:1386-1390(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Confirmation of the origin of NISCH syndrome."Hum. Mutat. 27:408-410(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry."Nature 446:801-805(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes."J. Invest. Dermatol. 133:1161-1169(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Production, purification and characterization of recombinant, full-length human claudin-1."PLoS ONE 8:E64517-E64517(2013) [PubMed] [Europe PMC] [Abstract]