Friend Leukemia Virus Integration 1 (FLI1)

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EWSR2; SIC1; Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB

Friend Leukemia Virus Integration 1 (FLI1)
Friend leukemia virus integration 1 is memeber of ETS transcription factor that first identified in erythroleukemias induced by Friend Murine Leukemia Virus (F-MuLV). Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias.
The constitutive activation of fli-1 in erythroblasts leads to a dramatic shift in the Epo/Epo-R signal transduction pathway, blocking erythroid differentiation, activating the Ras pathway, and resulting in massive Epo-independent proliferation of erythroblasts. These results suggest that Fli-1 overexpression in erythroblasts alters their responsiveness to Epo and triggers abnormal proliferation by switching the signaling event(s) associated with terminal differentiation to proliferation.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC492Hu01Recombinant Friend Leukemia Virus Integration 1 (FLI1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC492Hu01Polyclonal Antibody to Friend Leukemia Virus Integration 1 (FLI1)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Friend Leukemia Virus Integration 1 (FLI1)CLIA Kit Customized Service Offer
n/aELISA Kit for Friend Leukemia Virus Integration 1 (FLI1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Friend Leukemia Virus Integration 1 (FLI1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Friend Leukemia Virus Integration 1 (FLI1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Friend Leukemia Virus Integration 1 (FLI1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Friend Leukemia Virus Integration 1 (FLI1)CLIA Kit Customized Service Offer
n/aELISA Kit for Friend Leukemia Virus Integration 1 (FLI1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Friend Leukemia Virus Integration 1 (FLI1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Friend Leukemia Virus Integration 1 (FLI1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Friend Leukemia Virus Integration 1 (FLI1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Friend Leukemia Virus Integration 1 (FLI1)CLIA Kit Customized Service Offer
n/aELISA Kit for Friend Leukemia Virus Integration 1 (FLI1)ELISA Kit Customized Service Offer
  1. "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours."Nature 359:162-165(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors."Cell Growth Differ. 3:705-713(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and expression of human Fli-1 gene."Cancer Res. 52:5833-5837(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma."Biochim. Biophys. Acta 1172:155-158(1993) [PubMed] [Europe PMC] [Abstract]
  5. "The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24."Genomics 11:223-224(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Chromosome translocation based on illegitimate recombination in human tumors."Proc. Natl. Acad. Sci. U.S.A. 95:11786-11791(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma."Genes Chromosomes Cancer 13:126-132(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of the ets domain of Fli-1 when bound to DNA."Nat. Struct. Biol. 1:871-875(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structure of the SAM_pnt-domain of the human Friend leukemia integration 1 transcription factor."Submitted (NOV-2005) to the PDB data bank