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Glyoxalase I (GLO1)

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GLY-I; GLOD1; Glyoxalase Domain Containing 1; Lactoylglutathione lyase; Aldoketomutase; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase

Glyoxalase I (GLO1)
CCC C501
HGNC 4323
MGI 95742
PubMed 14641067
RGD 2702
UniProt Q04760
Wiki Glyoxalase_I
Glyoxalase I (EC 4.4.1.5) is a glutathione-binding protein involved in the detoxification of methylglyoxal, a byproduct of glycolysis. GLO1 and glyoxalase II (GLO2) catalyze successive steps in the pathway. GLO1 catalyzes condensation of methylglyoxal and reduced glutathione to form S-lactoyl-glutathione; GLO2 (hydroxyacyl glutathione hydrolase) converts the latter substance to D-lactic acid and reduced glutathione .The human enzyme showed 42% amino acid homology with bacterial Glo1. Northern blot analysis identified a 2.2-kb mRNA transcript in colon tissue. There was a 12-fold increase of the GLO1 transcript in colon carcinoma tissue compared to normal colon tissue from the same patient, and the authors concluded that GLO1 gene expression was induced in colon carcinoma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC501Hu01 Recombinant Glyoxalase I (GLO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC501Hu01 Polyclonal Antibody to Glyoxalase I (GLO1) WB; IHC; ICC; IP.
MAC501Hu22 Monoclonal Antibody to Glyoxalase I (GLO1) WB; IHC; ICC; IP.
Assay Kits SEC501Hu ELISA Kit for Glyoxalase I (GLO1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC501Mu01 Recombinant Glyoxalase I (GLO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC501Mu01 Polyclonal Antibody to Glyoxalase I (GLO1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glyoxalase I (GLO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glyoxalase I (GLO1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC501Ra01 Recombinant Glyoxalase I (GLO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC501Ra01 Polyclonal Antibody to Glyoxalase I (GLO1) WB; IHC; ICC; IP.
MAC501Ra21 Monoclonal Antibody to Glyoxalase I (GLO1) WB; IHC; ICC; IP.
Assay Kits SEC501Ra ELISA Kit for Glyoxalase I (GLO1) Enzyme-linked immunosorbent assay for Antigen Detection.
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