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Growth Hormone Releasing Hormone Receptor (GHRHR)

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GHRFR; GHRHRpsv; GRFR; Growth hormone-releasing factor receptor

Growth Hormone Releasing Hormone Receptor (GHRHR)
CCC C515
HGNC 4266
MGI 95710
PubMed 22489751
RGD 2688
UniProt Q02643
Wiki GHRHR
The growth hormone releasing hormone receptor (GHRHR) is a G-protein coupled receptor which binds growth hormone releasing hormone.This gene, expressed in the pituitary, encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone.
Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC515Hu01 Recombinant Growth Hormone Releasing Hormone Receptor (GHRHR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC515Hu01 Polyclonal Antibody to Growth Hormone Releasing Hormone Receptor (GHRHR) WB; IHC; ICC; IP.
Assay Kits SEC515Hu ELISA Kit for Growth Hormone Releasing Hormone Receptor (GHRHR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC515Mu01 Recombinant Growth Hormone Releasing Hormone Receptor (GHRHR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Growth Hormone Releasing Hormone Receptor (GHRHR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Hormone Releasing Hormone Receptor (GHRHR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Hormone Releasing Hormone Receptor (GHRHR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Hormone Releasing Hormone Receptor (GHRHR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Hormone Releasing Hormone Receptor (GHRHR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Hormone Releasing Hormone Receptor (GHRHR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Hormone Releasing Hormone Receptor (GHRHR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Hormone Releasing Hormone Receptor (GHRHR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Hormone Releasing Hormone Receptor (GHRHR) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone."Mol. Endocrinol. 6:1734-1744(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone."Mol. Endocrinol. 7:77-84(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor."Submitted (JUN-2010) to the PDB data bank
  5. "Three new mutations in the gene for the growth hormone (GH)-releasing hormone receptor in familial isolated GH deficiency type IB."J. Clin. Endocrinol. Metab. 86:273-279(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene."J. Clin. Endocrinol. Metab. 84:917-923(1999) [PubMed] [Europe PMC] [Abstract]
  7. "A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency."Eur. J. Endocrinol. 148:25-30(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]