Kinesin Light Chain 1 (KLC1)

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KLC; KNS2; KNS2A; hKLC1S; hKLC1N; hKLC1P; hKLC1G; hKLC1R; hKLC1J; hKLC1B; Kinesin 2

Kinesin Light Chain 1 (KLC1)

Kinesin 2 is a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se.

Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC554Hu01 Recombinant Kinesin Light Chain 1 (KLC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC554Hu01 Polyclonal Antibody to Kinesin Light Chain 1 (KLC1) WB; IHC; ICC; IP.
MAC554Hu22 Monoclonal Antibody to Kinesin Light Chain 1 (KLC1) WB; IHC; ICC; IP.
Assay Kits SEC554Hu ELISA Kit for Kinesin Light Chain 1 (KLC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Light Chain 1 (KLC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Light Chain 1 (KLC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Light Chain 1 (KLC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Light Chain 1 (KLC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Light Chain 1 (KLC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Light Chain 1 (KLC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Light Chain 1 (KLC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Light Chain 1 (KLC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Light Chain 1 (KLC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Light Chain 1 (KLC1) ELISA Kit Customized Service Offer
  1. "Cloning and genetic characterization of the human kinesin light-chain (KLC) gene."DNA Cell Biol. 12:881-892(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Alternatively spliced products of the human kinesin light chain 1 (KNS2) gene."Traffic 4:576-580(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The early onset dystonia protein torsinA interacts with kinesin light chain 1."J. Biol. Chem. 279:19882-19892(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement."Biochem. Soc. Trans. 38:205-208(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection."Cell Host Microbe 10:210-223(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of the TPR domain of kinesin light chain 1."Submitted (MAY-2011) to the PDB data bank