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Lamin B Receptor (LBR)

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DHCR14B; LMN2R; PHA; Integral nuclear envelope inner membrane protein

Lamin B Receptor (LBR)
CCC C577
HGNC 6518
MGI 2138281
PubMed 21327105
RGD 620813
UniProt Q14739
Wiki LBR
Lamin-B receptor is a protein belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. Phosphorylation of LBR and HP1 proteins may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lamin B Receptor (LBR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lamin B Receptor (LBR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lamin B Receptor (LBR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lamin B Receptor (LBR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lamin B Receptor (LBR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lamin B Receptor (LBR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lamin B Receptor (LBR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lamin B Receptor (LBR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lamin B Receptor (LBR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lamin B Receptor (LBR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lamin B Receptor (LBR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lamin B Receptor (LBR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lamin B Receptor (LBR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lamin B Receptor (LBR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lamin B Receptor (LBR) ELISA Kit Customized Service Offer
  1. "Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane."J. Biol. Chem. 269:11306-11311(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane."J. Biol. Chem. 269:11312-11317(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR."J. Biol. Chem. 272:14983-14989(1997) [PubMed] [Europe PMC] [Abstract]
  6. "SRPK1 and LBR protein kinases show identical substrate specificities."Biochem. Biophys. Res. Commun. 255:602-607(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Inner nuclear membrane protein LBR preferentially interacts with DNA secondary structures and nucleosomal linker."Biochemistry 39:6483-6488(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huet anomaly)."Nat. Genet. 31:410-414(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene."Am. J. Hum. Genet. 72:1013-1017(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain."Biochem. Biophys. Res. Commun. 331:929-937(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Temporal control of nuclear envelope assembly by phosphorylation of lamin B receptor."Mol. Biol. Cell 22:3306-3317(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Solution structure of the Tudor domain of human lamin-B receptor."Submitted (SEP-2006) to the PDB data bank
  20. "Solution structure of the Tudor domain of human lamin-B receptor."Submitted (FEB-2009) to the PDB data bank
  21. "Lamin B-receptor mutations in Pelger-Huet anomaly."Br. J. Haematol. 123:542-544(2003) [PubMed] [Europe PMC] [Abstract]
  22. "LBR mutation and nuclear envelope defects in a patient affected with Reynolds syndrome."J. Med. Genet. 47:361-370(2010) [PubMed] [Europe PMC] [Abstract]