Vanin 1 (VNN1)

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Pantetheinase; Pantetheine hydrolase; Tiff66; Vascular non-inflammatory molecule 1

Vanin 1 (VNN1)
Pantetheinase is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC598Hu01 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC598Hu02 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC598Hu03 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC598Hu04 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC598Hu05 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC598Hu01 Polyclonal Antibody to Vanin 1 (VNN1) WB
MAC598Hu22 Monoclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
PAC598Hu02 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
PAC598Hu03 Polyclonal Antibody to Vanin 1 (VNN1) WB
LAC598Hu71 Biotin-Linked Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC.
MAC598Hu24 Monoclonal Antibody to Vanin 1 (VNN1) WB
MAC598Hu21 Monoclonal Antibody to Vanin 1 (VNN1) WB
PAC598Hu04 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
Assay Kits SEC598Hu ELISA Kit for Vanin 1 (VNN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC598Mu01 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC598Mu01 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
LAC598Mu71 Biotin-Linked Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC.
Assay Kits SEC598Mu ELISA Kit for Vanin 1 (VNN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC598Ra01 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC598Ra01 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
MAC598Ra21 Monoclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
Assay Kits SEC598Ra ELISA Kit for Vanin 1 (VNN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC598Bo01 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC598Bo01 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Vanin 1 (VNN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vanin 1 (VNN1) ELISA Kit Customized Service Offer
  1. "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6."Genomics 53:203-213(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Is pantetheinase the actual identity of mouse and human vanin-1 proteins?"FEBS Lett. 461:149-152(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes."Immunogenetics 53:296-306(2001) [PubMed] [Europe PMC] [Abstract]
  7. "A proteomic analysis of human bile."Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines."J. Invest. Dermatol. 129:2167-2174(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]