Methyl CpG Binding Protein 2 (MECP2)


RTS; AUTSX3; MRX16; MRX79; PPMX; RTT; Rett Syndrome; Mental Retardation,X-linked 16

Methyl CpG Binding Protein 2 (MECP2)
MECP2 appears to be essential for the normal function of nerve cells. The protein seems to be particularly important for mature nerve cells, where it is present in high levels. The MeCP2 protein is likely to be involved in turning off ("repressing" or "silencing") several other genes. This prevents the genes from making proteins when they are not needed. Recent work has shown that MeCP2 can also activate other genes.The MECP2 gene is located on the long (q) arm of the X chromosome in band 28 ("Xq28"), from base pair 152,808,110 to base pair 152,878,611. MECP2 is dispensible in stem cells. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Organism species: Homo sapiens (Human)

ProteinsRPC616Hu01Recombinant Methyl CpG Binding Protein 2 (MECP2)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAC616Hu01Polyclonal Antibody to Methyl CpG Binding Protein 2 (MECP2)WB; IHC; ICC; IP.
MAC616Hu21Monoclonal Antibody to Methyl CpG Binding Protein 2 (MECP2)WB; IHC; ICC; IP.
Assay KitsSEC616HuELISA Kit for Methyl CpG Binding Protein 2 (MECP2)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

ProteinsRPC616Mu01Recombinant Methyl CpG Binding Protein 2 (MECP2)Positive Control; Immunogen; SDS-PAGE; WB.
RPC616Mu02Recombinant Methyl CpG Binding Protein 2 (MECP2)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAC616Mu01Polyclonal Antibody to Methyl CpG Binding Protein 2 (MECP2)WB; IHC; ICC; IP.
PAC616Mu02Polyclonal Antibody to Methyl CpG Binding Protein 2 (MECP2)WB; IHC; ICC; IP.
Assay KitsSEC616MuELISA Kit for Methyl CpG Binding Protein 2 (MECP2)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

Proteinsn/aRecombinant Methyl CpG Binding Protein 2 (MECP2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Methyl CpG Binding Protein 2 (MECP2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Methyl CpG Binding Protein 2 (MECP2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Methyl CpG Binding Protein 2 (MECP2)CLIA Kit Customized Service Offer
n/aELISA Kit for Methyl CpG Binding Protein 2 (MECP2)ELISA Kit Customized Service Offer
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  46. "Mutation analysis of the coding sequence of the MECP2 gene in infantile autism."Hum. Genet. 111:305-309(2002) [PubMed] [Europe PMC] [Abstract]
  47. "Identification of a family with nonspecific mental retardation (MRX79) with the A140V mutation in the MECP2 gene: is there a need for routine screening?"Hum. Mutat. 20:249-252(2002) [PubMed] [Europe PMC] [Abstract]
  48. "MECP2 gene nucleotide changes and their pathogenicity in males: proceed with caution."J. Med. Genet. 39:586-588(2002) [PubMed] [Europe PMC] [Abstract]
  49. "A Rett syndrome MECP2 mutation that causes mental retardation in men."Neurology 58:226-230(2002) [PubMed] [Europe PMC] [Abstract]
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  51. "Rett syndrome in a 47,XXX patient with a de novo MECP2 mutation."Am. J. Med. Genet. A 122:223-226(2003) [PubMed] [Europe PMC] [Abstract]
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  53. "Neurodevelopmental disorders in males related to the gene causing Rett syndrome in females (MECP2)."Eur. J. Paediatr. Neurol. 7:5-12(2003) [PubMed] [Europe PMC] [Abstract]
  54. "Identification of MeCP2 mutations in a series of females with autistic disorder."Pediatr. Neurol. 28:205-211(2003) [PubMed] [Europe PMC] [Abstract]
  55. "Phenotypic manifestations of MECP2 mutations in classical and atypical Rett syndrome."Am. J. Med. Genet. A 126:129-140(2004) [PubMed] [Europe PMC] [Abstract]
  56. "Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males."Am. J. Hum. Genet. 77:442-453(2005) [PubMed] [Europe PMC] [Abstract]
  57. "A novel familial MECP2 mutation in a young boy: clinical and molecular findings."Neurology 67:867-868(2006) [PubMed] [Europe PMC] [Abstract]
  58. "Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation."Proc. Natl. Acad. Sci. U.S.A. 104:2709-2714(2007) [PubMed] [Europe PMC] [Abstract]