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Microsomal Triglyceride Transfer Protein (MTTP)

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MTP; ABL; Microsomal triglyceride transfer protein large subunit

Microsomal Triglyceride Transfer Protein (MTTP)
CCC C641
HGNC 7467
MGI 106926
PubMed 17854051
RGD 1308388
UniProt P55157
Wiki MTTP
Microsomal triglyceride transfer protein, also known as MTTP or MTP, is the large subunit of the heterodimeric microsomal triaglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triaglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
Defects in MTTP are the cause of abetalipoproteinemia (ABL). ABL is an autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing lipoproteins.Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microsomal Triglyceride Transfer Protein (MTTP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microsomal Triglyceride Transfer Protein (MTTP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microsomal Triglyceride Transfer Protein (MTTP) Polyclonal Antibody Customized Service Offer
Assay Kits SEC641Hu ELISA Kit for Microsomal Triglyceride Transfer Protein (MTTP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC641Mu01 Recombinant Microsomal Triglyceride Transfer Protein (MTTP) Positive Control; Immunogen; SDS-PAGE; WB.
RPC641Mu02 Recombinant Microsomal Triglyceride Transfer Protein (MTTP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC641Mu01 Polyclonal Antibody to Microsomal Triglyceride Transfer Protein (MTTP) WB; IHC; ICC; IP.
PAC641Mu02 Polyclonal Antibody to Microsomal Triglyceride Transfer Protein (MTTP) WB; IHC; ICC; IP.
Assay Kits SEC641Mu ELISA Kit for Microsomal Triglyceride Transfer Protein (MTTP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microsomal Triglyceride Transfer Protein (MTTP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microsomal Triglyceride Transfer Protein (MTTP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microsomal Triglyceride Transfer Protein (MTTP) Polyclonal Antibody Customized Service Offer
Assay Kits SEC641Ra ELISA Kit for Microsomal Triglyceride Transfer Protein (MTTP) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia."Nature 365:65-69(1993) [PubMed] [Europe PMC] [Abstract]
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  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "A novel abetalipoproteinemia genotype. Identification of a missense mutation in the 97-kDa subunit of the microsomal triglyceride transfer protein that prevents complex formation with protein disulfide isomerase."J. Biol. Chem. 271:29945-29952(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Microsomal triglyceride transfer protein (MTP) gene mutations in Canadian subjects with abetalipoproteinemia."Hum. Mutat. 15:294-295(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia."J. Lipid Res. 41:1199-1204(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index."J. Lipid Res. 43:51-58(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Hypobetalipoproteinemia with an apparently recessive inheritance due to a 'de novo' mutation of apolipoprotein B."Biochim. Biophys. Acta 1688:61-67(2004) [PubMed] [Europe PMC] [Abstract]