Nibrin (NBN)

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AT-V1; AT-V2; ATV; NBS; NBS1; Nijmegen Breakage Syndrome 1; Cell cycle regulatory protein p95

Nibrin (NBN)
Nibrin is a protein associated with the repair of double strand breaks(DSBs) which pose serious damage to a genome. It is a 754 amino acid protein identified as a member of the NBS1/hMre11/RAD50(N/M/R, more commonly referred to as MRN) double strand DNA break repair complex.This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. It also has a role in regulation of N/M/R (MRN) protein complex activity which includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).Cellular response is performed by damage sensors, effectors of lesion repair and signal transduction. The central role is carried out by ataxia-telangiectasia mutated(ATM) by activating the DSB signaling cascade, phosphorylating downstream substrates such as histone H2AX and NBS1.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC679Hu01Recombinant Nibrin (NBN)SDS-PAGE; WB; ELISA; IP.
RPC679Hu02Recombinant Nibrin (NBN)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC679Hu01Polyclonal Antibody to Nibrin (NBN)WB, ICC, IHC-P, IHC-F, ELISA
LAC679Hu71Biotin-Linked Polyclonal Antibody to Nibrin (NBN)IHC;WB;ELISA
Assay Kitsn/aCLIA Kit for Nibrin (NBN)CLIA Kit Customized Service Offer
n/aELISA Kit for Nibrin (NBN)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Nibrin (NBN)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Nibrin (NBN)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Nibrin (NBN)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Nibrin (NBN)CLIA Kit Customized Service Offer
n/aELISA Kit for Nibrin (NBN)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Nibrin (NBN)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Nibrin (NBN)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Nibrin (NBN)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Nibrin (NBN)CLIA Kit Customized Service Offer
n/aELISA Kit for Nibrin (NBN)ELISA Kit Customized Service Offer
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  9. "Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization."Mol. Cell. Biol. 21:2184-2191(2001) [PubMed] [Europe PMC] [Abstract]
  10. "ATM-dependent phosphorylation of nibrin in response to radiation exposure."Nat. Genet. 25:115-119(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products."Nature 405:473-477(2000) [PubMed] [Europe PMC] [Abstract]
  12. "ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response."Nature 405:477-482(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres."Nat. Genet. 25:347-352(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein."Biochem. Biophys. Res. Commun. 299:863-871(2002) [PubMed] [Europe PMC] [Abstract]
  15. "NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain."Curr. Biol. 12:1846-1851(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1."J. Biol. Chem. 280:39594-39600(2005) [PubMed] [Europe PMC] [Abstract]
  17. "ATM-dependent phosphorylation of ATF2 is required for the DNA damage response."Mol. Cell 18:577-587(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage."Nature 434:605-611(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Nbs1 is required for ATR-dependent phosphorylation events."EMBO J. 24:199-208(2005) [PubMed] [Europe PMC] [Abstract]
  20. "The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control."Cell Res. 16:45-54(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex."Nature 418:348-352(2002) [PubMed] [Europe PMC] [Abstract]
  22. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells."Cancer Res. 67:8544-8553(2007) [PubMed] [Europe PMC] [Abstract]
  24. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  25. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  26. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  27. "N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair."J. Biol. Chem. 284:31746-31752(2009) [PubMed] [Europe PMC] [Abstract]
  28. "SOSS complexes participate in the maintenance of genomic stability."Mol. Cell 35:384-393(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  30. "Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex."J. Virol. 84:12504-12514(2010) [PubMed] [Europe PMC] [Abstract]
  31. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  32. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  33. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  34. "Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains."PLoS ONE 8:E65586-E65586(2013) [PubMed] [Europe PMC] [Abstract]
  35. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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  37. "Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility."J. Med. Genet. 40:E131-E131(2003) [PubMed] [Europe PMC] [Abstract]
  38. "Polymorphisms in DNA repair and metabolic genes in bladder cancer."Carcinogenesis 25:729-734(2004) [PubMed] [Europe PMC] [Abstract]
  39. "First case of aplastic anemia in a Japanese child with a homozygous missense mutation in the NBS1 gene (I171V) associated with genomic instability."Hum. Genet. 115:372-376(2004) [PubMed] [Europe PMC] [Abstract]
  40. "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]