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2',5'-Oligoadenylate Synthetase 1 (OAS1)

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2,5OAS1; 25-OAS1; OAS1; IFI-4; OIAS; OIASI; E18/E16

2',5'-Oligoadenylate Synthetase 1 (OAS1)
CCC C684
HGNC 8086
MGI 97429
PubMed 15855350
RGD 621760
UniProt P00973
Wiki OAS1
2'-5'-oligoadenylate synthetase 1 is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection.
The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC684Hu01 Recombinant 2',5'-Oligoadenylate Synthetase 1 (OAS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC684Hu01 Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 1 (OAS1) WB; IHC; ICC; IP.
MAC684Hu22 Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 1 (OAS1) WB,IHC
LAC684Hu71 Biotin-Linked Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 1 (OAS1) WB; IHC; ICC.
MAC684Hu21 Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 1 (OAS1) WB; IHC; ICC; IP.
MAC684Hu23 Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 1 (OAS1) WB; IHC; ICC; IP.
MAC684Hu24 Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 1 (OAS1) WB; IHC; ICC; IP.
Assay Kits SEC684Hu ELISA Kit for 2',5'-Oligoadenylate Synthetase 1 (OAS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC684Mu01 Recombinant 2',5'-Oligoadenylate Synthetase 1 (OAS1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC684Mu02 Recombinant 2',5'-Oligoadenylate Synthetase 1 (OAS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC684Mu01 Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 1 (OAS1) WB; IHC; ICC; IP.
PAC684Mu02 Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 1 (OAS1) WB; IHC; ICC; IP.
Assay Kits SEC684Mu ELISA Kit for 2',5'-Oligoadenylate Synthetase 1 (OAS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC684Ra01 Recombinant 2',5'-Oligoadenylate Synthetase 1 (OAS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC684Ra01 Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 1 (OAS1) WB; IHC; ICC; IP.
MAC684Ra21 Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 1 (OAS1) WB; IHC; ICC; IP.
Assay Kits SEC684Ra ELISA Kit for 2',5'-Oligoadenylate Synthetase 1 (OAS1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences."EMBO J. 4:2249-2256(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon."FEBS Lett. 196:113-120(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase."J. Biochem. 99:1455-1464(1986) [PubMed] [Europe PMC] [Abstract]
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  5. "The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla."J. Mol. Evol. 63:562-576(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "New inducers revealed by the promoter sequence analysis of two interferon-activated human genes."Eur. J. Biochem. 169:313-321(1987) [PubMed] [Europe PMC] [Abstract]
  10. "Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene."Mol. Cell. Biol. 7:4498-4504(1987) [PubMed] [Europe PMC] [Abstract]
  11. "Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene."EMBO J. 7:751-759(1988) [PubMed] [Europe PMC] [Abstract]
  12. "Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure."EMBO J. 4:1761-1768(1985) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular cloning and sequence of partial cDNA for interferon-induced (2'-5')oligo(A) synthetase mRNA from human cells."Proc. Natl. Acad. Sci. U.S.A. 80:4904-4908(1983) [PubMed] [Europe PMC] [Abstract]
  14. "Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein."J. Biol. Chem. 272:33220-33226(1997) [PubMed] [Europe PMC] [Abstract]
  15. "The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases."J. Biol. Chem. 274:25535-25542(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family."Nucleic Acids Res. 31:3166-3173(2003) [PubMed] [Europe PMC] [Abstract]
  17. "The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation."Biochimie 89:779-788(2007) [PubMed] [Europe PMC] [Abstract]
  18. "The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain."J. Gen. Virol. 89:2767-2772(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection."J. Immunol. 183:8035-8043(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Differential regulation of the OASL and OAS1 genes in response to viral infections."J. Interferon Cytokine Res. 29:199-207(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria."J. Mol. Evol. 69:612-624(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities."J. Interferon Cytokine Res. 31:41-47(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1."Proc. Natl. Acad. Sci. U.S.A. 110:1652-1657(2013) [PubMed] [Europe PMC] [Abstract]