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Ornithine Decarboxylase Antizyme 1 (OAZ1)

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AZI; OAZ; ODC-Az

Ornithine Decarboxylase Antizyme 1 (OAZ1)
CCC C685
HGNC 8095
MGI 109433
PubMed 12888889
RGD 3219
UniProt P54368
Wiki OAZ1
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting.
Ornithine decarboxylase antizyme inhibits ornithine decarboxylase and accelerates its degradation.Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC685Hu01 Recombinant Ornithine Decarboxylase Antizyme 1 (OAZ1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC685Hu01 Polyclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) WB; IHC; ICC; IP.
MAC685Hu22 Monoclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) WB; IHC; ICC; IP.
Assay Kits SEC685Hu ELISA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ornithine Decarboxylase Antizyme 1 (OAZ1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ornithine Decarboxylase Antizyme 1 (OAZ1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) ELISA Kit Customized Service Offer
  1. "Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme."Biochim. Biophys. Acta 1209:293-295(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of human antizyme cDNA."Biochem. Mol. Biol. Int. 38:957-964(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the human antizyme gene."Gene 203:131-139(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)."BMC Cell Biol. 3:15-15(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase."Biochem. J. 409:187-192(2008) [PubMed] [Europe PMC] [Abstract]