Prosaposin (PSAP)


SAP1; GLBA; CSAct; Dispersin; Pro-Saposin; Proactivator polypeptide; Glucosylceramidase activator; Sulfatide/GM1 activator; Cerebroside sulfate activator; Sphingolipid Activator 1

Prosaposin (PSAP)
Prosaposin also known as PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Saposin is an acronym for Sphingolipid Activator PrO[S]teINs. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities.Saposins A-D are required for the hydrolysis of certain shingolipids by specific lysosomal hydrolases.

Organism species: Homo sapiens (Human)

ProteinsRPC756Hu01Recombinant Prosaposin (PSAP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC756Hu01Polyclonal Antibody to Prosaposin (PSAP)WB, ICC, IHC-P, IHC-F, ELISA
MAC756Hu22Monoclonal Antibody to Prosaposin (PSAP)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC756HuELISA Kit for Prosaposin (PSAP)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

Proteinsn/aRecombinant Prosaposin (PSAP)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Prosaposin (PSAP)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Prosaposin (PSAP)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Prosaposin (PSAP)CLIA Kit Customized Service Offer
n/aELISA Kit for Prosaposin (PSAP)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

Proteinsn/aRecombinant Prosaposin (PSAP)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Prosaposin (PSAP)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Prosaposin (PSAP)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Prosaposin (PSAP)CLIA Kit Customized Service Offer
n/aELISA Kit for Prosaposin (PSAP)ELISA Kit Customized Service Offer
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  23. "Structure of the asparagine-linked sugar chains of porcine kidney and human urine cerebroside sulfate activator protein."J. Mass Spectrom. 35:1416-1424(2000) [PubMed] [Europe PMC] [Abstract]
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  25. "The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin."EMBO J. 22:6430-6437(2003) [PubMed] [Europe PMC] [Abstract]
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  39. "An Asn > Lys substitution in saposin B involving a conserved amino acidic residue and leading to the loss of the single N-glycosylation site in a patient with metachromatic leukodystrophy and normal arylsulphatase A activity."Eur. J. Hum. Genet. 7:125-130(1999) [PubMed] [Europe PMC] [Abstract]
  40. "A non-glycosylated and functionally deficient mutant (N215H) of the sphingolipid activator protein B (SAP-B) in a novel case of metachromatic leukodystrophy (MLD)."J. Inherit. Metab. Dis. 23:63-76(2000) [PubMed] [Europe PMC] [Abstract]
  41. "A novel mutation in the coding region of the prosaposin gene leads to a complete deficiency of prosaposin and saposins, and is associated with a complex sphingolipidosis dominated by lactosylceramide accumulation."Hum. Mol. Genet. 10:927-940(2001) [PubMed] [Europe PMC] [Abstract]
  42. "A mutation in the saposin A coding region of the prosaposin gene in an infant presenting as Krabbe disease: first report of saposin A deficiency in humans."Mol. Genet. Metab. 84:160-166(2005) [PubMed] [Europe PMC] [Abstract]
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