≡

Toll Interacting Protein (TOLLIP)

[Edit]

IL-1RAcPIP

Toll Interacting Protein (TOLLIP)
CCC C803
HGNC 16476
MGI 1891808
PubMed 10854325
RGD 1304676
UniProt Q9H0E2
Wiki TOLLIP
Toll interacting protein, also known as TOLLIP, is an inhibitory adaptor protein .It is an inhibitory adaptor protein within Toll-like receptors (TLR). The TLR pathway is a part of the innate immune system that recognizes structurally conserved molecular patterns of microbial pathogens, leading to an inflammatory immune response.
Compared with the full-length isoform, 2 of the human proteins lack the N-terminal TBD, and 1 lacks the C2 domain. A mouse-specific isoform lacks the C-terminal CUE domain. EST database analysis suggested that full-length human TOLLIP is ubiquitously expressed. Expression of the other human variants appeared to be more restricted, with evidence for enrichment in brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC803Hu01 Recombinant Toll Interacting Protein (TOLLIP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC803Hu01 Polyclonal Antibody to Toll Interacting Protein (TOLLIP) WB; IHC; ICC; IP.
MAC803Hu21 Monoclonal Antibody to Toll Interacting Protein (TOLLIP) WB; IHC; ICC; IP.
Assay Kits SEC803Hu ELISA Kit for Toll Interacting Protein (TOLLIP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC803Mu01 Recombinant Toll Interacting Protein (TOLLIP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC803Mu01 Polyclonal Antibody to Toll Interacting Protein (TOLLIP) WB; IHC
Assay Kits n/a CLIA Kit for Toll Interacting Protein (TOLLIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Toll Interacting Protein (TOLLIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Toll Interacting Protein (TOLLIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Toll Interacting Protein (TOLLIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Toll Interacting Protein (TOLLIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Toll Interacting Protein (TOLLIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Toll Interacting Protein (TOLLIP) ELISA Kit Customized Service Offer
  1. "Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor."Nat. Cell Biol. 2:346-351(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Negative regulation of Toll-like receptor-mediated signaling by Tollip."J. Biol. Chem. 277:7059-7065(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Recruitment of clathrin onto endosomes by the Tom1-Tollip complex."Biochem. Biophys. Res. Commun. 341:143-149(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Autophagic clearance of PolyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family."Cell 158:549-563(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of CUE domain in the C-terminal of human Toll-interacting protein (TOLLIP)."Submitted (NOV-2004) to the PDB data bank