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Thymopoietin (TMPO)

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TP; LAP2; CMD1T; LEMD4; TP5; Splenin; Lamina-Associated Polypeptide 2,Isoforms Beta/Gamma; LEM Domain Containing 4; Thymopoietin-related peptide isoforms beta/gamma

Thymopoietin (TMPO)
CCC C824
HGNC 11875
MGI 106920
PubMed 16247757
RGD 3875
UniProt P42167
Wiki Thymopoietin
Thymopoietin is a protein involved in the induction of CD90 in the thymus. The thymopoetin (TMPO) gene encodes three alternatively spliced mRNAs encoding proteins of 75 kDa (alpha), 51 kDa (beta) and 39 kDa (gamma) which are ubiquitously expressed in all cells. The human TMPO gene maps to chromosome band 12q22 and consists of eight exons. TMPO alpha is present diffusely expressed with the cell nucleus while TMPO beta and gamma are localized to the nuclear membrane. TMPO beta is a human homolog of the murine protein LAP2 (lamina-associated polypeptide 2). LAP2 plays a role in the regulation of nuclear architecture by binding lamin B1 and chromosomes. This interaction is regulated by phosphorylation during mitosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC824Hu01 Recombinant Thymopoietin (TMPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC824Hu01 Polyclonal Antibody to Thymopoietin (TMPO) WB; IHC; ICC; IP.
MAC824Hu21 Monoclonal Antibody to Thymopoietin (TMPO) WB; IHC; ICC; IP.
Assay Kits SEC824Hu ELISA Kit for Thymopoietin (TMPO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thymopoietin (TMPO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thymopoietin (TMPO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thymopoietin (TMPO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thymopoietin (TMPO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thymopoietin (TMPO) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thymopoietin (TMPO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thymopoietin (TMPO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thymopoietin (TMPO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thymopoietin (TMPO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thymopoietin (TMPO) ELISA Kit Customized Service Offer
  1. "Three distinct human thymopoietins are derived from alternatively spliced mRNAs."Proc. Natl. Acad. Sci. U.S.A. 91:6283-6287(1994) [PubMed] [Europe PMC] [Abstract]
  2. "LAP2zeta binds BAF and suppresses LAP2beta-mediated transcriptional repression."Eur. J. Cell Biol. 87:267-278(2008) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
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  6. "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin."Eur. J. Biochem. 251:729-733(1998) [PubMed] [Europe PMC] [Abstract]
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  10. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
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  14. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
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  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA."EMBO J. 20:4399-4407(2001) [PubMed] [Europe PMC] [Abstract]
  25. "Structural characterization of the LEM motif common to three human inner nuclear membrane proteins."Structure 9:503-511(2001) [PubMed] [Europe PMC] [Abstract]