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Renalase (RNLS)

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MAO-C; C10orf59; FAD-Dependent Amine Oxidase; Monoamine oxidase-C; alpha-NAD(P)H oxidase/anomerase

Renalase (RNLS)
CCC C845
HGNC 25641
MGI 96621
PubMed 21099685
UniProt Q5VYX0
Wiki Renalase
The renalase protein is an enzyme which breaks down catecholamines like adrenaline (epinephrine) and noradrenaline (norepinephrine) in the blood circulation. Researchers at Yale School of Medicine who discovered and named renalase in 2005 suggest that the human kidney releases this protein into the bloodstream to regulate blood pressure.
The renalase protein consists of a secretory signal peptide, a flavin adenine dinucleotide (FAD)-binding region, and an amine oxidase domain. At least four alternative splicing isoforms have been identified in humans (hRenalase1 to hRenalase4). Only hRenalase1 is detected in human blood samples, which means that hRenalase2 to 4 probably have a different function than hRenalase1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC845Hu01 Recombinant Renalase (RNLS) Positive Control; Immunogen; SDS-PAGE; WB.
RPC845Hu02 Recombinant Renalase (RNLS) Positive Control; Immunogen; SDS-PAGE; WB.
RPC845Hu03 Recombinant Renalase (RNLS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC845Hu01 Polyclonal Antibody to Renalase (RNLS) WB; IHC; ICC; IP.
MAC845Hu22 Monoclonal Antibody to Renalase (RNLS) WB
LAC845Hu71 Biotin-Linked Polyclonal Antibody to Renalase (RNLS) WB; IHC; ICC.
PAC845Hu02 Polyclonal Antibody to Renalase (RNLS) WB; IHC; ICC; IP.
MAC845Hu21 Monoclonal Antibody to Renalase (RNLS) WB; IHC; ICC; IP.
MAC845Hu23 Monoclonal Antibody to Renalase (RNLS) WB; IHC; ICC; IP.
MAC845Hu25 Monoclonal Antibody to Renalase (RNLS) WB
Assay Kits SEC845Hu ELISA Kit for Renalase (RNLS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC845Mu02 Recombinant Renalase (RNLS) Positive Control; Immunogen; SDS-PAGE; WB.
RPC845Mu01 Recombinant Renalase (RNLS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC845Mu01 Polyclonal Antibody to Renalase (RNLS) WB; IHC; ICC; IP.
PAC845Mu02 Polyclonal Antibody to Renalase (RNLS) WB; IHC; ICC; IP.
LAC845Mu71 Biotin-Linked Polyclonal Antibody to Renalase (RNLS) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Renalase (RNLS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Renalase (RNLS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC845Ra01 Recombinant Renalase (RNLS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC845Ra01 Polyclonal Antibody to Renalase (RNLS) WB; IHC; ICC; IP.
MAC845Ra21 Monoclonal Antibody to Renalase (RNLS) WB; IHC; ICC; IP.
Assay Kits SEC845Ra ELISA Kit for Renalase (RNLS) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure."J. Clin. Invest. 115:1275-1280(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Renalase, a catecholamine-metabolising enzyme?"J. Neural Transm. 114:775-776(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Renalase is an alpha-NAD(P)H oxidase/anomerase."J. Am. Chem. Soc. 135:13980-13987(2013) [PubMed] [Europe PMC] [Abstract]
  7. "FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation."J. Mol. Biol. 411:463-473(2011) [PubMed] [Europe PMC] [Abstract]