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S-Phase Kinase Associated Protein 2 (SKP2)

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FBL1; FBXL1; FLB1; p45; Cyclin-A/CDK2-associated protein p45; F-box/LRR-repeat protein 1; p45skp2

S-Phase Kinase Associated Protein 2 (SKP2)
CCC C847
HGNC 10901
MGI 1351663
PubMed 12769843
RGD 1562456
UniProt Q13309
Wiki SKP2
S-phase kinase-associated protein 2 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC847Hu01 Recombinant S-Phase Kinase Associated Protein 2 (SKP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC847Hu01 Polyclonal Antibody to S-Phase Kinase Associated Protein 2 (SKP2) WB; IHC; ICC; IP.
MAC847Hu21 Monoclonal Antibody to S-Phase Kinase Associated Protein 2 (SKP2) WB; IHC; ICC; IP.
Assay Kits SEC847Hu ELISA Kit for S-Phase Kinase Associated Protein 2 (SKP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant S-Phase Kinase Associated Protein 2 (SKP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to S-Phase Kinase Associated Protein 2 (SKP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to S-Phase Kinase Associated Protein 2 (SKP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for S-Phase Kinase Associated Protein 2 (SKP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for S-Phase Kinase Associated Protein 2 (SKP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant S-Phase Kinase Associated Protein 2 (SKP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to S-Phase Kinase Associated Protein 2 (SKP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to S-Phase Kinase Associated Protein 2 (SKP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for S-Phase Kinase Associated Protein 2 (SKP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for S-Phase Kinase Associated Protein 2 (SKP2) ELISA Kit Customized Service Offer
  1. "p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase."Cell 82:915-925(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2)."Genes Dev. 16:2946-2957(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication."Mol. Cell 9:481-491(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation."J. Biol. Chem. 278:30854-30858(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription."Mol. Cell 11:1189-1200(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase."J. Biol. Chem. 279:46424-46430(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection."Biochemistry 44:14553-14564(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle."Mol. Cell 18:699-709(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation."J. Virol. 79:11135-11141(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation."Proc. Natl. Acad. Sci. U.S.A. 102:1649-1654(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination."Cancer Res. 66:8477-8483(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  16. "The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2."Mol. Cell. Biol. 26:3114-3123(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein."Mol. Cell. Biol. 26:5994-6004(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions."Genes Dev. 21:2385-2398(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Ubiquitination and degradation of Tal1/SCL are induced by Notch signaling and depend on Skp2 and CHIP."J. Biol. Chem. 283:684-692(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control."Proc. Natl. Acad. Sci. U.S.A. 108:9119-9124(2011) [PubMed] [Europe PMC] [Abstract]
  26. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Acetylation-dependent regulation of Skp2 function."Cell 150:179-193(2012) [PubMed] [Europe PMC] [Abstract]
  28. "Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex."Nature 408:381-386(2000) [PubMed] [Europe PMC] [Abstract]
  29. "Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex."Nature 416:703-709(2002) [PubMed] [Europe PMC] [Abstract]