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Synaptopodin (SYNPO)

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Synaptopodin (SYNPO)
CCC C885
HGNC 30672
MGI 1099446
PubMed 16622418
RGD 620668
UniProt Q8N3V7
Wiki SYNPO
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes.
Mouse and human SYNPO share 84% amino acid identity. SYNPO contains a high proline content (20%), making it unlikely that SYNPO forms a globular domain. It has several potential phosphorylation sites and 2 PPxY motifs, which interact with WW domain proteins. Northern blot analysis of human cerebral cortex detected a 4.4-kb transcript. Western blot analysis detected synaptopodin in rat brain beginning at embryonic day 15, with maximal expression in adult animals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC885Hu01 Recombinant Synaptopodin (SYNPO) Positive Control; Immunogen; SDS-PAGE; WB.
RPC885Hu02 Recombinant Synaptopodin (SYNPO) Positive Control; Immunogen; SDS-PAGE; WB.
RPC885Hu03 Recombinant Synaptopodin (SYNPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC885Hu01 Polyclonal Antibody to Synaptopodin (SYNPO) WB; IHC; ICC; IP.
MAC885Hu22 Monoclonal Antibody to Synaptopodin (SYNPO) WB; IHC; ICC; IP.
PAC885Hu03 Polyclonal Antibody to Synaptopodin (SYNPO) WB; IHC; ICC; IP.
Assay Kits SEC885Hu ELISA Kit for Synaptopodin (SYNPO) Enzyme-linked immunosorbent assay for Antigen Detection.
AEC885Hu ELISA Kit for Anti-Synaptopodin Antibody (Anti-SYNPO) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synaptopodin (SYNPO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synaptopodin (SYNPO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synaptopodin (SYNPO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synaptopodin (SYNPO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synaptopodin (SYNPO) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synaptopodin (SYNPO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synaptopodin (SYNPO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synaptopodin (SYNPO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synaptopodin (SYNPO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synaptopodin (SYNPO) ELISA Kit Customized Service Offer
  1. "Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes."J. Cell Biol. 139:193-204(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1."J. Biol. Chem. 277:30183-30190(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "KIBRA modulates directional migration of podocytes."J. Am. Soc. Nephrol. 19:1891-1903(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]