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Dermcidin (DCD)

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HCAP; AIDD; DCD1; DSEP; PIF; Proteolysis Inducing Factor; Preproteolysin; Diffusible Survival/Evasion Peptide; Survival Promoting Peptide

Dermcidin (DCD)
CCC C896
HGNC 14669
PubMed 11694882
UniProt P81605
Wiki Dermcidin
Dermcidin is a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients.
High performance liquid chromatography, mass spectrometry, and microsequence analysis of sweat showed a processed 47-amino acid DCD peptide with a calculated mass of 4.7 kD, compared with the expected 9.3 kD of full-length DCD without the signal peptide.DCD expression in skin, melanocytic nevus, and cutaneous melanoma tissue, but not in any other organ systems tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC896Hu01 Recombinant Dermcidin (DCD) Positive Control; Immunogen; SDS-PAGE; WB.
CPC896Hu21 OVA Conjugated Dermcidin (DCD) Immunogen; SDS-PAGE; WB.
Antibodies PAC896Hu01 Polyclonal Antibody to Dermcidin (DCD) WB; IHC; ICC; IP.
MAC896Hu22 Monoclonal Antibody to Dermcidin (DCD) WB; IHC; ICC; IP.
LAC896Hu71 Biotin-Linked Polyclonal Antibody to Dermcidin (DCD) WB; IHC; ICC.
Assay Kits SEC896Hu ELISA Kit for Dermcidin (DCD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC896Ra01 Recombinant Dermcidin (DCD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC896Ra01 Polyclonal Antibody to Dermcidin (DCD) WB; IHC; ICC; IP.
MAC896Ra21 Monoclonal Antibody to Dermcidin (DCD) WB; IHC; ICC; IP.
Assay Kits SEC896Ra ELISA Kit for Dermcidin (DCD) Enzyme-linked immunosorbent assay for Antigen Detection.
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  10. "Analysis of the solution structure of the human antibiotic peptide dermcidin and its interaction with phospholipid vesicles."BMB Rep. 43:362-368(2010) [PubMed] [Europe PMC] [Abstract]