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Cathepsin C (CTSC)

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CTS-C; DPPI; CPPI; DPP1; DPP-I; HMS; JP; JPD; PALS; PLS; Dipeptidyl Peptidase I; Dipeptidyl transferase; Cathepsin J

Cathepsin C (CTSC)
CCC C965
HGNC 2528
MGI 109553
PubMed 14974080
RGD 2445
UniProt P53634
Wiki Cathepsin_C
Cathepsin C (dipeptidyl peptidase I) is a lysosomal exo-cysteine protease belonging to the peptidase C1 family. Cathepsin C appears to be a central coordinator for activation of many serine proteases in immune/inflammatory cells.Cathepsin C catalyses excision of dipeptides from the N-terminus of protein and peptide substrates, except if (i) the amino group of the N-terminus is blocked, (ii) the site of cleavage is on either side of a proline residue, (iii) the N-terminal residue is lysine or arginine, or (iv) the structure of the peptide or protein prevents further digestion from the N-terminus.Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre disease, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC965Hu01 Recombinant Cathepsin C (CTSC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC965Hu01 Polyclonal Antibody to Cathepsin C (CTSC) WB; IHC; ICC; IP.
MAC965Hu22 Monoclonal Antibody to Cathepsin C (CTSC) WB; IHC; ICC; IP.
Assay Kits SEC965Hu ELISA Kit for Cathepsin C (CTSC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC965Mu01 Recombinant Cathepsin C (CTSC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC965Mu01 Polyclonal Antibody to Cathepsin C (CTSC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cathepsin C (CTSC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cathepsin C (CTSC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cathepsin C (CTSC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cathepsin C (CTSC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cathepsin C (CTSC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cathepsin C (CTSC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cathepsin C (CTSC) ELISA Kit Customized Service Offer
  1. "Molecular cloning and sequence analysis of human preprocathepsin C."FEBS Lett. 369:326-330(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Human dipeptidyl-peptidase I. Gene characterization, localization, and expression."J. Biol. Chem. 272:10260-10265(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Cathepsin C gene: first compound heterozygous patient with Papillon-Lefevre syndrome and a novel symptomless mutation."Hum. Mutat. 17:152-153(2001) [PubMed] [Europe PMC] [Abstract]
  4. "A genetic study of cathepsin C gene in two families with Papillon-Lefevre syndrome."Mol. Genet. Metab. 79:146-148(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Stoichiometry and heterogeneity of the pro-region chain in tetrameric human cathepsin C."Biochim. Biophys. Acta 1382:143-150(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Oligomeric structure and substrate induced inhibition of human cathepsin C."J. Biol. Chem. 270:21626-21631(1995) [PubMed] [Europe PMC] [Abstract]
  11. "The residual pro-part of cathepsin C fulfills the criteria required for an intramolecular chaperone in folding and stabilizing the human proenzyme."Biochemistry 39:12382-12390(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Purification and characterization of dipeptidyl peptidase I from human spleen."Arch. Biochem. Biophys. 295:280-288(1992) [PubMed] [Europe PMC] [Abstract]
  13. "Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms."Cell 136:272-283(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases."EMBO J. 20:6570-6582(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis." Nat. Genet. 23:421-424(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Haim-Munk syndrome and Papillon-Lefevre syndrome are allelic mutations in cathepsin C."J. Med. Genet. 37:88-94(2000) [PubMed] [Europe PMC] [Abstract]
  20. "Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation."J. Med. Genet. 37:95-101(2000) [PubMed] [Europe PMC] [Abstract]
  21. "Identification of cathepsin C mutations in ethnically diverse Papillon-Lefevre syndrome patients."J. Med. Genet. 37:927-932(2000) [PubMed] [Europe PMC] [Abstract]
  22. "Papillon-Lefevre syndrome: mutations and polymorphisms in the cathepsin C gene."J. Invest. Dermatol. 116:339-343(2001) [PubMed] [Europe PMC] [Abstract]
  23. "Novel point mutations, deletions, and polymorphisms in the cathepsin C gene in nine families from Europe and North Africa with Papillon-Lefevre syndrome."J. Invest. Dermatol. 117:1657-1661(2001) [PubMed] [Europe PMC] [Abstract]
  24. "Evidence of a founder effect for four cathepsin C gene mutations in Papillon-Lefevre syndrome patients."J. Med. Genet. 38:96-101(2001) [PubMed] [Europe PMC] [Abstract]
  25. "Biochemical and mutational analyses of the cathepsin c gene (CTSC) in three North American families with Papillon Lefevre syndrome."Hum. Mutat. 20:75-75(2002) [PubMed] [Europe PMC] [Abstract]
  26. "The role of cathepsin C in Papillon-Lefevre syndrome, prepubertal periodontitis, and aggressive periodontitis." Hum. Mutat. 23:222-228(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Loss-of-function mutations in cathepsin C in two families with Papillon-Lefevre syndrome are associated with deficiency of serine proteinases in PMNs."Hum. Mutat. 23:524-524(2004) [PubMed] [Europe PMC] [Abstract]
  28. "Gene symbol: CTSC. Disease: Papillon-Lefevre syndrome."Hum. Genet. 116:545-545(2005) [PubMed] [Europe PMC] [Abstract]
  29. ErratumHum. Genet. 118:533-533(2005)