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Complement Component 6 (C6)

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Complement Component 6 (C6)
CCC C976
HGNC 1339
MGI 88233
PubMed 15568620
RGD 2238
UniProt P13671
Wiki C6

C6 is 1 of 5 late-acting proteins of complement that participate in assembly and function of the MAC (DiScipio and Hugli, 1989). The deduced C6 protein contains 934 amino acids, including a 21-amino acid N-terminal signal sequence and 2 N-glycosylation sites. The mature 913-amino acid C6 protein shares 29% amino acid identity with C7 , and 55 of 56 cysteines in C7 match those in C6.

The C6 polypeptide chain is cross-linked by 32 disulfide bonds, and most cysteines are located in short, discrete segments that exhibit homology with a variety of proteins, including thrombospondin, low density lipoprotein receptor(LDLR), epidermal growth factor (EGF), and complement factors H (CFH) and I (CFI ).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC976Hu01 Recombinant Complement Component 6 (C6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC976Hu01 Polyclonal Antibody to Complement Component 6 (C6) WB; IHC; ICC; IP.
MAC976Hu22 Monoclonal Antibody to Complement Component 6 (C6) WB; IHC; ICC; IP.
Assay Kits SEC976Hu ELISA Kit for Complement Component 6 (C6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complement Component 6 (C6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complement Component 6 (C6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Component 6 (C6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Component 6 (C6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 6 (C6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complement Component 6 (C6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complement Component 6 (C6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Component 6 (C6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Component 6 (C6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 6 (C6) ELISA Kit Customized Service Offer
  1. "Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6."J. Biol. Chem. 264:18041-18051(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The molecular architecture of human complement component C6."J. Biol. Chem. 264:16197-16206(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of the human C6 gene."Biochemistry 32:6198-6205(1993) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Structural homology of complement protein C6 with other channel-forming proteins of complement."Proc. Natl. Acad. Sci. U.S.A. 86:2799-2803(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Elucidation of the disulfide-bonding pattern in the factor I modules of the sixth component (C6) of human complement."Biochim. Biophys. Acta 1342:13-18(1997) [PubMed] [Europe PMC] [Abstract]
  8. "The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues."J. Biol. Chem. 274:32786-32794(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC)."J. Biol. Chem. 287:10210-10222(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Polymorphism of human complement component C6: an amino acid substitution (Glu/Ala) within the second thrombospondin repeat differentiates between the two common allotypes C6 A and C6 B."Biochem. Biophys. Res. Commun. 194:458-464(1993) [PubMed] [Europe PMC] [Abstract]
  13. "Meningococccal meningitis and complement component 6 deficiency associated with oculocutaneous albinism."Eur. J. Pediatr. 164:177-179(2005) [PubMed] [Europe PMC] [Abstract]