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Arginyl tRNA Synthetase (RARS)

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ArgRS; DALRD1; Arginine tRNA Ligase 1,Cytoplasmic

Arginyl tRNA Synthetase (RARS)
CCC C997
HGNC 9870
MGI 1914297
PubMed 19187230
RGD 1309215
UniProt P54136
Wiki RARS_(gene
Arginyl-tRNA synthetase, cytoplasmic is an enzyme encoded by the RARS gene.Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family.Knockdown of rrt1, and of most other genes encoding aminoacyl-tRNA synthetases, rescued animals from hypoxia-induced death, and the level of hypoxia resistance was inversely correlated with translation rate. The unfolded protein response was induced by hypoxia and was required for the hypoxia resistance of the reduction-of-function mutant of rrt1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC997Hu01 Recombinant Arginyl tRNA Synthetase (RARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC997Hu01 Polyclonal Antibody to Arginyl tRNA Synthetase (RARS) WB; IHC; ICC; IP.
MAC997Hu22 Monoclonal Antibody to Arginyl tRNA Synthetase (RARS) WB
MAC997Hu21 Monoclonal Antibody to Arginyl tRNA Synthetase (RARS) WB; IHC; ICC; IP.
MAC997Hu25 Monoclonal Antibody to Arginyl tRNA Synthetase (RARS) WB; IHC; ICC; IP.
MAC997Hu23 Monoclonal Antibody to Arginyl tRNA Synthetase (RARS) WB; IHC; ICC; IP.
MAC997Hu24 Monoclonal Antibody to Arginyl tRNA Synthetase (RARS) WB; IHC; ICC; IP.
MAC997Hu29 Monoclonal Antibody to Arginyl tRNA Synthetase (RARS) IHC
MAC997Hu27 Monoclonal Antibody to Arginyl tRNA Synthetase (RARS) WB; IHC; ICC; IP.
Assay Kits SEC997Hu ELISA Kit for Arginyl tRNA Synthetase (RARS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arginyl tRNA Synthetase (RARS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arginyl tRNA Synthetase (RARS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arginyl tRNA Synthetase (RARS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arginyl tRNA Synthetase (RARS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arginyl tRNA Synthetase (RARS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arginyl tRNA Synthetase (RARS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arginyl tRNA Synthetase (RARS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arginyl tRNA Synthetase (RARS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arginyl tRNA Synthetase (RARS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arginyl tRNA Synthetase (RARS) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of cDNA encoding a human arginyl-tRNA synthetase."Gene 164:347-350(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase."J. Biol. Chem. 274:16673-16676(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex."J. Biol. Chem. 280:34755-34763(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Two forms of human cytoplasmic arginyl-tRNA synthetase produced from two translation initiations by a single mRNA."Biochemistry 45:1338-1344(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines."J. Cell. Physiol. 212:293-297(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  13. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures." Am. J. Hum. Genet. 94:547-558(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations in RARS cause hypomyelination."Ann. Neurol. 76:134-139(2014) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]