Acetylcholine Receptor (AChR)


Acetylcholinergic Receptor

Acetylcholine Receptor (AChR)

An acetylcholine receptor is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter. The nAChRs are ligand-gated ion channels, and, like other members of the "cys-loop" ligand-gated ion channel superfamily, are composed of five protein subunits symmetrically arranged like staves around a barrel. The subunit composition is highly variable across different tissues. Each subunit contains four regions which span the membrane and consist of approximately 20 amino acids. Region II which sits closest to the pore lumen, forms the pore lining. Binding of acetylcholine to the N termini of each of the two alpha subunits results in the 15° rotation of all M2 helices. The cytoplasm side of the nAChR receptor has rings of high negative charge that determine the specific cation specificity of the receptor and remove the hydration shell often formed by ions in aqueous solution.



Organism species: Homo sapiens (Human)

Proteins n/a Complete Antigen of Acetylcholine Receptor (AChR) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acetylcholine Receptor (AChR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acetylcholine Receptor (AChR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acetylcholine Receptor (AChR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acetylcholine Receptor (AChR) ELISA Kit Customized Service Offer