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Low Density Lipoprotein Receptor Related Protein 6 (LRP6)

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Low Density Lipoprotein Receptor Related Protein 6 (LRP6)
CCC D105
HGNC 6698
MGI 1298218
PubMed 18505367
RGD 1304749
UniProt O75581
Wiki LRP6
The LRP6 is a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD105Hu01 Recombinant Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD105Hu01 Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 6 (LRP6) WB; IHC; ICC; IP.
MAD105Hu21 Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 6 (LRP6) WB; IHC; ICC; IP.
LAD105Hu71 Biotin-Linked Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 6 (LRP6) WB; IHC; ICC.
MAD105Hu22 Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 6 (LRP6) WB; IHC; ICC; IP.
MAD105Hu23 Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 6 (LRP6) WB; IHC; ICC; IP.
MAD105Hu24 Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 6 (LRP6) WB; IHC; ICC; IP.
Assay Kits SED105Hu ELISA Kit for Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Low Density Lipoprotein Receptor Related Protein 6 (LRP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Low Density Lipoprotein Receptor Related Protein 6 (LRP6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Low Density Lipoprotein Receptor Related Protein 6 (LRP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Low Density Lipoprotein Receptor Related Protein 6 (LRP6) ELISA Kit Customized Service Offer
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  8. "SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor."J. Biol. Chem. 280:26770-26775(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation."Nature 438:873-877(2005) [PubMed] [Europe PMC] [Abstract]
  10. "The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway."Genes Dev. 20:1933-1945(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation."J. Biol. Chem. 281:12233-12241(2006) [PubMed] [Europe PMC] [Abstract]
  12. "R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling."J. Biol. Chem. 282:15903-15911(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Regulated proteolytic processing of LRP6 results in release of its intracellular domain."J. Neurochem. 101:517-529(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor."Mol. Cell. Biol. 27:7291-7301(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation."Science 316:1619-1622(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6."J. Biol. Chem. 283:16115-16123(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling."PLoS ONE 3:E4046-E4046(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum."Proc. Natl. Acad. Sci. U.S.A. 105:5384-5389(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Cell cycle control of wnt receptor activation."Dev. Cell 17:788-799(2009) [PubMed] [Europe PMC] [Abstract]
  20. "G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway."J. Biol. Chem. 284:35040-35048(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6."PLoS ONE 4:E4926-E4926(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6."J. Biol. Chem. 285:9172-9179(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation."Mol. Cell. Biol. 31:2577-2590(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Disabled-2 (Dab2) inhibits Wnt/beta-catenin signalling by binding LRP6 and promoting its internalization through clathrin."EMBO J. 31:2336-2349(2012) [PubMed] [Europe PMC] [Abstract]
  25. "ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner."Nature 485:195-200(2012) [PubMed] [Europe PMC] [Abstract]
  26. "Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6."Dev. Cell 21:862-873(2011) [PubMed] [Europe PMC] [Abstract]
  27. "LRP6 mutation in a family with early coronary disease and metabolic risk factors."Science 315:1278-1282(2007) [PubMed] [Europe PMC] [Abstract]