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Intrinsic factor is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 later on in the terminal ileum.
Upon entry into the stomach, vitamin B12 becomes bound to haptocorrin (R factor), a glycoprotein. The resulting complex enters the duodenum, where pancreatic enzymes digest haptocorrin. In the less acidic environment of the small intestine, B12 can then bind to intrinsic factor. This new complex travels to the ileum, where special epithelial cells endocytose them. Inside the cell, B12 dissociate once again and bind to another protein, transcobalamin II. The new complex can exit the epithelial cells to enter the liver.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD111Hu01 | Recombinant Gastric Intrinsic Factor (GIF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| CPD111Hu31 | KLH Conjugated Gastric Intrinsic Factor (GIF) | Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAD111Hu01 | Polyclonal Antibody to Gastric Intrinsic Factor (GIF) | WB; IHC; ICC; IP. |
| MAD111Hu21 | Monoclonal Antibody to Gastric Intrinsic Factor (GIF) | WB; IHC; ICC; IP. | |
| PAD111Hu02 | Polyclonal Antibody to Gastric Intrinsic Factor (GIF) | WB; IHC; ICC; IP. | |
| PAD111Hu08 | Polyclonal Antibody to Gastric Intrinsic Factor (GIF) | WB; IHC; ICC; IP. | |
| Assay Kits | CED111Hu | ELISA Kit for Gastric Intrinsic Factor (GIF) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD111Mu01 | Recombinant Gastric Intrinsic Factor (GIF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD111Mu01 | Polyclonal Antibody to Gastric Intrinsic Factor (GIF) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Gastric Intrinsic Factor (GIF) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Gastric Intrinsic Factor (GIF) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD111Ra01 | Recombinant Gastric Intrinsic Factor (GIF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD111Ra01 | Polyclonal Antibody to Gastric Intrinsic Factor (GIF) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Gastric Intrinsic Factor (GIF) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Gastric Intrinsic Factor (GIF) | ELISA Kit Customized Service Offer |
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- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution."Proc. Natl. Acad. Sci. U.S.A. 104:17311-17316(2007) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes."Nature 464:445-448(2010) [PubMed] [Europe PMC] [Abstract]
- "A genetic polymorphism in the coding region of the gastric intrinsic factor gene (GIF) is associated with congenital intrinsic factor deficiency."Hum. Mutat. 23:85-91(2004) [PubMed] [Europe PMC] [Abstract]
- "Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene."Proc. Natl. Acad. Sci. U.S.A. 102:4130-4133(2005) [PubMed] [Europe PMC] [Abstract]