Chemokine C-C-Motif Ligand 4 Like Protein 1 (CCL4L1)


LAG1; CCL4L; LAG1; SCYA4L; Monocyte adherence-induced protein 5-alpha; Small-inducible cytokine A4-like; Lymphocyte activation gene 1; Macrophage inflammatory 1-beta

Chemokine C-C-Motif Ligand 4 Like Protein 1 (CCL4L1)
C-C motif chemokine 4-like is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein is similar to CCL4 which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals; most individuals have 1-5 copies in the diploid genome, although rare individuals do not contain this gene at all. The human genome reference assembly contains two copies of this gene. This record represents the more centromeric gene.Modi et al. (2001) stated that ACT2 is synonymous with CCL4, SCYA4, and MIP1B, while LAG1 is synonymous with CCL4L and SCYA4L.Colobran et al. (2005) showed that both CCL4 and CCL4L generate splice variants lacking exon 2.

Organism species: Homo sapiens (Human)

Proteins RPD160Hu01 Recombinant Chemokine C-C-Motif Ligand 4 Like Protein 1 (CCL4L1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD160Hu01 Polyclonal Antibody to Chemokine C-C-Motif Ligand 4 Like Protein 1 (CCL4L1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Chemokine C-C-Motif Ligand 4 Like Protein 1 (CCL4L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine C-C-Motif Ligand 4 Like Protein 1 (CCL4L1) ELISA Kit Customized Service Offer
  1. "Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients."J. Immunol. 174:5655-5664(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The human MIP-1beta chemokine is encoded by two paralogous genes, ACT-2 and LAG-1."Immunogenetics 53:543-549(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Functional redundancy of the human CCL4 and CCL4L1 chemokine genes."Biochem. Biophys. Res. Commun. 320:927-931(2004) [PubMed] [Europe PMC] [Abstract]
  5. "CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12."Genomics 83:735-738(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Independent expression of the two paralogous CCL4 genes in monocytes and B lymphocytes."Immunogenetics 55:706-711(2004) [PubMed] [Europe PMC] [Abstract]
  7. "CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection."Genes Immun. 8:224-231(2007) [PubMed] [Europe PMC] [Abstract]