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Lipase, Monoacylglycerol (MGL)

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HU-K5, MGLL; MAGL; Monoglyceride Lipase; Lysophospholipase homolog; Lysophospholipase-like; Monoacylglycerol lipase

Lipase, Monoacylglycerol (MGL)
CCC D223
HGNC 17038
MGI 1346042
PubMed 22542104
RGD 71039
UniProt Q99685
Wiki MGL
MAGL is a 33-kDa, membrane-associated member of the serine hydrolase superfamily and contains the classical GXSXG consensus sequence common to most serine hydrolases.
Monoacylglycerol lipase functions together with hormone-sensitive lipase (LIPE) to hydrolyze intracellular triglyceride stores in adipocytes and other cells to fatty acids and glycerol. MGLL may also complement lipoprotein lipase (LPL) in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides.Monoacylglycerol lipase is a key enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol. It converts monoacylglycerols to the free fatty acid and glycerol.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD223Hu01 Recombinant Lipase, Monoacylglycerol (MGL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD223Hu01 Polyclonal Antibody to Lipase, Monoacylglycerol (MGL) WB; IHC; ICC; IP.
MAD223Hu21 Monoclonal Antibody to Lipase, Monoacylglycerol (MGL) WB; IHC; ICC; IP.
Assay Kits SED223Hu ELISA Kit for Lipase, Monoacylglycerol (MGL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lipase, Monoacylglycerol (MGL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lipase, Monoacylglycerol (MGL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lipase, Monoacylglycerol (MGL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lipase, Monoacylglycerol (MGL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lipase, Monoacylglycerol (MGL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lipase, Monoacylglycerol (MGL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lipase, Monoacylglycerol (MGL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lipase, Monoacylglycerol (MGL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lipase, Monoacylglycerol (MGL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lipase, Monoacylglycerol (MGL) ELISA Kit Customized Service Offer
  1. "A novel poxvirus gene and its human homolog are similar to an E. coli lysophospholipase."Virus Res. 52:157-167(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene."Gene 272:11-18(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
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  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis."Cell 140:49-61(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Biochemical and pharmacological characterization of human alpha/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)."J. Lipid Res. 53:2413-2424(2012) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling."ChemBioChem 11:218-227(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Structural basis for human monoglyceride lipase inhibition."J. Mol. Biol. 396:663-673(2010) [PubMed] [Europe PMC] [Abstract]