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Lipase, Gastric (LIPF)

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HGL; HLAL; Gastric lipase

Lipase, Gastric (LIPF)
CCC D226
HGNC 6622
MGI 1914967
PubMed 3181673
RGD 708441
UniProt P07098
Wiki LIPF
Gastric lipase is an acidic lipase secreted by the gastric chief cells in the fundic mucosa in the stomach. It has a pH optimum of 3-6. Gastric lipase, together with lingual lipase, comprise the two acidic lipases. These lipases, unlike alkaline lipases (such as pancreatic lipase), do not require bile acid or colipase for optimal enzymatic activity. Acidic lipases make up 30% of lipid hydrolysis occurring during digestion in the human adult, with gastric lipase contributing the most of the two acidic lipases. In neonates, acidic lipases are much more important, providing up to 50% of total lipolytic activity.Gastric lipase is a polypeptide of 371 residues in length. The structure of gastric lipase was determined using X-ray diffraction with a resolution of 3.00 Å, and is composed of 41% helices and 14% beta sheets.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD226Hu01 Recombinant Lipase, Gastric (LIPF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD226Hu01 Polyclonal Antibody to Lipase, Gastric (LIPF) WB; IHC; ICC; IP.
MAD226Hu21 Monoclonal Antibody to Lipase, Gastric (LIPF) WB; IHC; ICC; IP.
Assay Kits SED226Hu ELISA Kit for Lipase, Gastric (LIPF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lipase, Gastric (LIPF) Recombinant Protein Customized Service Offer
Antibodies PAD226Mu01 Polyclonal Antibody to Lipase, Gastric (LIPF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Lipase, Gastric (LIPF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lipase, Gastric (LIPF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lipase, Gastric (LIPF) Recombinant Protein Customized Service Offer
Antibodies PAD226Ra01 Polyclonal Antibody to Lipase, Gastric (LIPF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Lipase, Gastric (LIPF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lipase, Gastric (LIPF) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a human gastric lipase and expression of the enzyme in yeast."Biochim. Biophys. Acta 909:237-244(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human gastric lipase. The N-terminal tetrapeptide is essential for lipid binding and lipase activity."Eur. J. Biochem. 182:495-499(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest."J. Biol. Chem. 274:16995-17002(1999) [PubMed] [Europe PMC] [Abstract]