Cyclin A (CCNA)
Cyclin-A2 is a protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.Cell cycle regulation of the CCNA promoter is mediated by sequences extending from -79 to +100 relative to the predominant transcription start site. The presence of a functional retinoblastoma protein is not required.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin A (CCNA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin A (CCNA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin A (CCNA) Polyclonal Antibody Customized Service Offer
Assay Kits SED262Hu ELISA Kit for Cyclin A (CCNA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin A (CCNA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin A (CCNA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin A (CCNA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin A (CCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin A (CCNA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin A (CCNA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin A (CCNA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin A (CCNA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin A (CCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin A (CCNA) ELISA Kit Customized Service Offer
  1. "Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma."Nature 343:555-557(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and cell cycle-regulated transcription of the human cyclin A gene."Proc. Natl. Acad. Sci. U.S.A. 91:5490-5494(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression."J. Cell Biol. 178:621-633(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry."Mol. Cell 42:511-523(2011) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state."Proc. Natl. Acad. Sci. U.S.A. 110:17510-17515(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex."Nature 376:313-320(1995) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex."Nature 382:325-331(1996) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis of cyclin-dependent kinase activation by phosphorylation."Nat. Struct. Biol. 3:696-700(1996) [PubMed] [Europe PMC] [Abstract]
  15. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]