Cyclin G Associated Kinase (GAK)
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5.Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cyclin G Associated Kinase (GAK)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cyclin G Associated Kinase (GAK)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cyclin G Associated Kinase (GAK)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cyclin G Associated Kinase (GAK)CLIA Kit Customized Service Offer
n/aELISA Kit for Cyclin G Associated Kinase (GAK)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cyclin G Associated Kinase (GAK)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cyclin G Associated Kinase (GAK)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cyclin G Associated Kinase (GAK)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cyclin G Associated Kinase (GAK)CLIA Kit Customized Service Offer
n/aELISA Kit for Cyclin G Associated Kinase (GAK)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cyclin G Associated Kinase (GAK)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cyclin G Associated Kinase (GAK)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cyclin G Associated Kinase (GAK)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cyclin G Associated Kinase (GAK)CLIA Kit Customized Service Offer
n/aELISA Kit for Cyclin G Associated Kinase (GAK)ELISA Kit Customized Service Offer
  1. "Structure, expression, and chromosomal localization of human GAK."Genomics 44:179-187(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells."J. Biol. Chem. 275:1365-1370(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of the human cyclin G associated kinase (GAK)."Submitted (JUL-2011) to the PDB data bank
  13. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]