Cytochrome P450 1A1 (CYP1A1)


CYP1; AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX; Cytochrome P450,Subfamily I(Aromatic Compound-Inducible),Polypeptide 1

Cytochrome P450 1A1 (CYP1A1)
CYP1A1 is involved in phase I xenobiotic and drug metabolism (one substrate of it is theophylline). It is inhibited by fluoroquinolones and macrolides and induced by aromatic hydrocarbons.
CYP1A1 is also known as AHH (aryl hydrocarbon hydroxylase). It is involved in the metabolic activation of aromatic hydrocarbons (polycyclic aromatic hydrocarbons, PAH), for example, benzopyrene (BP), by transforming it to an epoxide. In this reaction, the oxidation of benzo[a]pyrene is catalysed by CYP1A1 to form BP-7,8-epoxide, which can be further oxidized by epoxide hydrolase (EH) to form BP-7,8-dihydrodiol. Finally CYP1A1 catalyses this intermediate to form BP-7,8-dihydrodiol-9,10-epoxide, which is the ultimate carcinogen.

Organism species: Homo sapiens (Human)

ProteinsRPD295Hu01Recombinant Cytochrome P450 1A1 (CYP1A1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD295Hu01Polyclonal Antibody to Cytochrome P450 1A1 (CYP1A1)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAD295Hu21Monoclonal Antibody to Cytochrome P450 1A1 (CYP1A1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSED295HuELISA Kit for Cytochrome P450 1A1 (CYP1A1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

ProteinsRPD295Mu01Recombinant Cytochrome P450 1A1 (CYP1A1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD295Mu01Polyclonal Antibody to Cytochrome P450 1A1 (CYP1A1)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Cytochrome P450 1A1 (CYP1A1)CLIA Kit Customized Service Offer
n/aELISA Kit for Cytochrome P450 1A1 (CYP1A1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

ProteinsRPD295Ra01Recombinant Cytochrome P450 1A1 (CYP1A1)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
AntibodiesPAD295Ra01Polyclonal Antibody to Cytochrome P450 1A1 (CYP1A1)WB, ICC, IHC-P, IHC-F, ELISA
MAD295Ra21Monoclonal Antibody to Cytochrome P450 1A1 (CYP1A1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSED295RaELISA Kit for Cytochrome P450 1A1 (CYP1A1)Enzyme-linked immunosorbent assay for Antigen Detection
  1. "Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism."Nucleic Acids Res. 13:4503-4520(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence."Science 228:80-83(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and drug inducibility of the human cytochrome P-450c gene."Eur. J. Biochem. 159:219-225(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation."Pharmacogenetics 11:1-6(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of cytochrome P450 1A1 in human brain."Biochem. Biophys. Res. Commun. 243:808-810(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6."DNA 4:395-400(1985) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism."J. Biol. Chem. 288:12932-12943(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene."J. Biochem. 110:407-411(1991) [PubMed] [Europe PMC] [Abstract]
  12. "A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility."Cancer Res. 56:4965-4969(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms."Pharmacogenetics 10:11-24(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population."Hum. Mutat. 17:355-355(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Novel nonsynonymous polymorphisms of the CYP1A1 Gene in Japanese."Drug Metab. Pharmacokinet. 18:218-222(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus."Hum. Mutat. 25:196-206(2005) [PubMed] [Europe PMC] [Abstract]
  18. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]