Hexokinase 2 (HK2)

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HK II; Muscle form hexokinase

Hexokinase 2 (HK2)
Hexokinase II is the major hexokinase expressed in skeletal muscle. Insulin has been shown to increase transcription of this gene. Lehto et al. (1993) described the isolation of genomic clones for human hexokinase-2. These clones were isolated by screening a human placental genomic library with a rat hexokinase-2 cDNA clone. A genomic clone derived from this screening was used in fluorescence in situ hybridization studies and was found to map to human chromosome 2p13.1. The human HK2 genomic clones were also screened for dinucleotide repeats. Primers were selected to amplify an approximately 224-bp CA-repeat-rich region. This repeat region was highly polymorphic; the level of heterozygosity was 0.63 in Caucasians and 0.51 in Chinese subjects.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD352Hu01 Recombinant Hexokinase 2 (HK2) Positive Control; Immunogen; SDS-PAGE; WB.
RPD352Hu02 Recombinant Hexokinase 2 (HK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD352Hu01 Polyclonal Antibody to Hexokinase 2 (HK2) WB; IHC; ICC; IP.
MAD352Hu21 Monoclonal Antibody to Hexokinase 2 (HK2) WB; IHC; ICC; IP.
PAD352Hu02 Polyclonal Antibody to Hexokinase 2 (HK2) WB; IHC; ICC; IP.
Assay Kits SED352Hu ELISA Kit for Hexokinase 2 (HK2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD352Mu01 Recombinant Hexokinase 2 (HK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD352Mu01 Polyclonal Antibody to Hexokinase 2 (HK2) WB; IHC; ICC; IP.
LAD352Mu81 FITC-Linked Polyclonal Antibody to Hexokinase 2 (HK2) WB; IHC; ICC; IF
LAD352Mu71 Biotin-Linked Polyclonal Antibody to Hexokinase 2 (HK2) WB; IHC; ICC.
Assay Kits SED352Mu ELISA Kit for Hexokinase 2 (HK2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hexokinase 2 (HK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hexokinase 2 (HK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hexokinase 2 (HK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hexokinase 2 (HK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hexokinase 2 (HK2) ELISA Kit Customized Service Offer
  1. "Human hexokinase II: sequence and homology to other hexokinases."Biochem. Biophys. Res. Commun. 197:68-74(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity."Diabetologia 38:1466-1474(1995) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Steady state transcript levels of the type II hexokinase and type 1 glucose transporter in human tumor cell lines."Cancer Lett. 82:27-32(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of human hexokinase II."Submitted (DEC-2006) to the PDB data bank
  7. "Amino acid substitutions in hexokinase II among patients with NIDDM."Diabetes 44:330-334(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution."Diabetes 44:340-346(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity."Diabetes 44:347-353(1995) [PubMed] [Europe PMC] [Abstract]