Hexokinase 2 (HK2)

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HK II; Muscle form hexokinase

Hexokinase 2 (HK2)
Hexokinase II is the major hexokinase expressed in skeletal muscle. Insulin has been shown to increase transcription of this gene. Lehto et al. (1993) described the isolation of genomic clones for human hexokinase-2. These clones were isolated by screening a human placental genomic library with a rat hexokinase-2 cDNA clone. A genomic clone derived from this screening was used in fluorescence in situ hybridization studies and was found to map to human chromosome 2p13.1. The human HK2 genomic clones were also screened for dinucleotide repeats. Primers were selected to amplify an approximately 224-bp CA-repeat-rich region. This repeat region was highly polymorphic; the level of heterozygosity was 0.63 in Caucasians and 0.51 in Chinese subjects.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD352Hu01Recombinant Hexokinase 2 (HK2)SDS-PAGE; WB; ELISA; IP.
RPD352Hu02Recombinant Hexokinase 2 (HK2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD352Hu01Polyclonal Antibody to Hexokinase 2 (HK2)WB, ICC, IHC-P, IHC-F, ELISA
MAD352Hu21Monoclonal Antibody to Hexokinase 2 (HK2)WB, ICC, IHC-P, IHC-F, ELISA
PAD352Hu02Polyclonal Antibody to Hexokinase 2 (HK2)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSED352HuELISA Kit for Hexokinase 2 (HK2)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD352Mu01Recombinant Hexokinase 2 (HK2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD352Mu01Polyclonal Antibody to Hexokinase 2 (HK2)WB, ICC, IHC-P, IHC-F, ELISA
LAD352Mu81FITC-Linked Polyclonal Antibody to Hexokinase 2 (HK2)IHC;ICC;IF;WB
LAD352Mu71Biotin-Linked Polyclonal Antibody to Hexokinase 2 (HK2)IHC;WB;ELISA
Assay KitsSED352MuELISA Kit for Hexokinase 2 (HK2)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Hexokinase 2 (HK2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Hexokinase 2 (HK2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Hexokinase 2 (HK2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Hexokinase 2 (HK2)CLIA Kit Customized Service Offer
n/aELISA Kit for Hexokinase 2 (HK2)ELISA Kit Customized Service Offer
  1. "Human hexokinase II: sequence and homology to other hexokinases."Biochem. Biophys. Res. Commun. 197:68-74(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity."Diabetologia 38:1466-1474(1995) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Steady state transcript levels of the type II hexokinase and type 1 glucose transporter in human tumor cell lines."Cancer Lett. 82:27-32(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of human hexokinase II."Submitted (DEC-2006) to the PDB data bank
  7. "Amino acid substitutions in hexokinase II among patients with NIDDM."Diabetes 44:330-334(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution."Diabetes 44:340-346(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity."Diabetes 44:347-353(1995) [PubMed] [Europe PMC] [Abstract]