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Kruppel Like Factor 1, Erythroid (KLF1)

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EKLF; Erythroid krueppel-like transcription factor

Kruppel Like Factor 1, Erythroid (KLF1)
CCC D368
HGNC 6345
MGI 1342771
PubMed 22835905
RGD 1309398
UniProt Q13351
Wiki Klf1
Erythroid Krüppel-like Factor (EKLF) is a transcription factor that is necessary for the proper maturation of erythroid (red blood) cells. The molecule has two domains; the transactivation domain and the chromatin-remodeling domain. The carboxyl (C) terminal is composed of three C2H2 zinc fingers that binds to DNA, and the amino (N) terminus is proline rich and acidic. The gene for EKLF is on the human chromosome 19 and on mouse chromosome 8.
EKLF deficient (knockout) mouse embryos exhibit a lethal anemic phenotype, fail to promote the transcription of adult β globin, and die by embryonic day 14. On the other hand, over-expression of EKLF results in a reduction of the number of circulating platelets and hastens the onset of β globin gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kruppel Like Factor 1, Erythroid (KLF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kruppel Like Factor 1, Erythroid (KLF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kruppel Like Factor 1, Erythroid (KLF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kruppel Like Factor 1, Erythroid (KLF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kruppel Like Factor 1, Erythroid (KLF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD368Mu01 Recombinant Kruppel Like Factor 1, Erythroid (KLF1) Positive Control; Immunogen; SDS-PAGE; WB.
RPD368Mu02 Recombinant Kruppel Like Factor 1, Erythroid (KLF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD368Mu01 Polyclonal Antibody to Kruppel Like Factor 1, Erythroid (KLF1) WB; IHC; ICC; IP.
PAD368Mu02 Polyclonal Antibody to Kruppel Like Factor 1, Erythroid (KLF1) WB; IHC; ICC; IP.
Assay Kits SED368Mu ELISA Kit for Kruppel Like Factor 1, Erythroid (KLF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kruppel Like Factor 1, Erythroid (KLF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kruppel Like Factor 1, Erythroid (KLF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kruppel Like Factor 1, Erythroid (KLF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kruppel Like Factor 1, Erythroid (KLF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kruppel Like Factor 1, Erythroid (KLF1) ELISA Kit Customized Service Offer
  1. "Isolation, genomic structure, and expression of human erythroid Kruppel-like factor (EKLF)."DNA Cell Biol. 15:347-352(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13."Genomics 39:393-395(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Acetylation and modulation of erythroid Krueppel-like factor (EKLF) activity by interaction with histone acetyltransferases."Proc. Natl. Acad. Sci. U.S.A. 95:9855-9860(1998) [PubMed] [Europe PMC] [Abstract]
  6. "A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia." Am. J. Hum. Genet. 87:721-727(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin." Nat. Genet. 42:801-805(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF)."Proc. Natl. Acad. Sci. U.S.A. 108:10484-10489(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype."Blood 112:2081-2088(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Compound heterozygosity for KLF1 mutations is associated with microcytic hypochromic anemia and increased fetal hemoglobin."Eur. J. Hum. Genet. 0:0-0(2015) [PubMed] [Europe PMC] [Abstract]