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Fructose-1,6-Bisphosphatase (FBP)

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FBP1; FBPase 1; Liver FBPase; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1

Fructose-1,6-Bisphosphatase (FBP)
CCC D404
HGNC 3606
MGI 95492
PubMed 16332851
RGD 2595
UniProt P09467
Wiki FBP
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
By physical mapping with FISH and by genetic mapping of an associated GA repeat polymorphism, Rothschild et al. (1995) mapped the hepatic FBP gene to 9q22.3. Amplification using FBP exon-specific primers with a YAC contig from this region of chromosome 9 further refined the placement of FBP genomic sequences to an approximately 1.7-cM flanked by D9S289 and D9S287, near the gene for Fanconi anemia group C.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD404Hu01 Recombinant Fructose-1,6-Bisphosphatase (FBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Fructose-1,6-Bisphosphatase (FBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fructose-1,6-Bisphosphatase (FBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fructose-1,6-Bisphosphatase (FBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fructose-1,6-Bisphosphatase (FBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fructose-1,6-Bisphosphatase (FBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fructose-1,6-Bisphosphatase (FBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fructose-1,6-Bisphosphatase (FBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fructose-1,6-Bisphosphatase (FBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fructose-1,6-Bisphosphatase (FBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fructose-1,6-Bisphosphatase (FBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fructose-1,6-Bisphosphatase (FBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fructose-1,6-Bisphosphatase (FBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fructose-1,6-Bisphosphatase (FBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fructose-1,6-Bisphosphatase (FBP) ELISA Kit Customized Service Offer
  1. "Activation of the fructose 1,6-bisphosphatase gene by 1,25-dihydroxyvitamin D3 during monocytic differentiation."Proc. Natl. Acad. Sci. U.S.A. 85:6904-6908(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of a human liver fructose-1,6-bisphosphatase cDNA and expression of the protein in Escherichia coli. Role of Asp-118 and Asp-121 in catalysis."J. Biol. Chem. 268:9466-9472(1993) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA sequences encoding human fructose 1,6-bisphosphatase from monocytes, liver and kidney: application of monocytes to molecular analysis of human fructose 1,6-bisphosphatase deficiency."Biochem. Biophys. Res. Commun. 199:687-693(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency."Genomics 27:520-525(1995) [PubMed] [Europe PMC] [Abstract]
  5. "cDNA sequence and kinetic properties of human lung fructose(1, 6)bisphosphatase."Arch. Biochem. Biophys. 365:1-9(1999) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Liver fructose-1,6-bisphosphatase cDNA: trans-complementation of fission yeast and characterization of two human transcripts."Differentiation 59:51-60(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis."Endocrinology 147:2764-2772(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Glu 69 is essential for the high sensitivity of muscle fructose-1,6-bisphosphatase inhibition by calcium ions."FEBS Lett. 581:1347-1350(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function."Diabetes 57:1887-1895(2008) [PubMed] [Europe PMC] [Abstract]
  12. "The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity."Diabetes 61:1122-1132(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase."Biochemistry 32:1844-1857(1993) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 2,6-bisphosphate, AMP, and Zn2+ at 2.0-A resolution: aspects of synergism between inhibitors."Proc. Natl. Acad. Sci. U.S.A. 91:12482-12486(1994) [PubMed] [Europe PMC] [Abstract]
  16. "Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase."Bioorg. Med. Chem. Lett. 16:1807-1810(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode."Bioorg. Med. Chem. Lett. 16:1811-1815(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites."Bioorg. Med. Chem. Lett. 18:4708-4712(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency."Am. J. Hum. Genet. 61:852-861(1997) [PubMed] [Europe PMC] [Abstract]
  20. "Two newly identified genomic mutations in a Japanese female patient with fructose-1,6-bisphosphatase (FBPase) deficiency."Mol. Genet. Metab. 76:207-210(2002) [PubMed] [Europe PMC] [Abstract]