Phosphofructokinase, Muscle (PFKM)

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PFK1; PFKX; Phosphofructokinase 1; Phosphofructo-1-kinase isozyme A; 6-Phosphofructokinase Polypeptide X; Fructose-6-Phosphate 1-Phosphotransferase

Phosphofructokinase, Muscle (PFKM)
Phosphofructokinase-1 (PFK-1) is the most important regulatory enzyme (EC 2.7.1.11) of glycolysis. It is an allosteric enzyme made of 4 subunits and controlled by several activators and inhibitors. PFK-1 catalyzes one of the important "committed" steps of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose 1,6-bisphosphate and ADP.
PFK1 is allosterically inhibited by ATP and citrate (from the citric acid cycle) and its product. It is also inhibited by low pH to prevent the accumulation of hydrogen ions in muscle. The enzyme has two sites with different affinities for ATP which is both a substrate and an inhibitor.PFK1 is allosterically activated by a high concentration of AMP, but the most potent activator is fructose 2,6-bisphosphate, which is also produced from fructose-6-phosphate by PFK2.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD405Hu01Recombinant Phosphofructokinase, Muscle (PFKM)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD405Hu01Polyclonal Antibody to Phosphofructokinase, Muscle (PFKM)WB, ICC, IHC-P, IHC-F, ELISA
MAD405Hu21Monoclonal Antibody to Phosphofructokinase, Muscle (PFKM)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSED405HuELISA Kit for Phosphofructokinase, Muscle (PFKM)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Phosphofructokinase, Muscle (PFKM)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Phosphofructokinase, Muscle (PFKM)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Phosphofructokinase, Muscle (PFKM)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Phosphofructokinase, Muscle (PFKM)CLIA Kit Customized Service Offer
n/aELISA Kit for Phosphofructokinase, Muscle (PFKM)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD405Ra01Recombinant Phosphofructokinase, Muscle (PFKM)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD405Ra01Polyclonal Antibody to Phosphofructokinase, Muscle (PFKM)WB, ICC, IHC-P, IHC-F, ELISA
MAD405Ra21Monoclonal Antibody to Phosphofructokinase, Muscle (PFKM)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSED405RaELISA Kit for Phosphofructokinase, Muscle (PFKM)Enzyme-linked immunosorbent assay for Antigen Detection
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