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Myosin Binding Protein C, Slow Type (MYBPC1)

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MYBPCC; MYBPCS; C-protein, skeletal muscle slow isoform

Myosin Binding Protein C, Slow Type (MYBPC1)
CCC D413
HGNC 7549
MGI 1924741
PubMed 23873045
UniProt Q00872
Wiki MYBPC1
Myosin-binding protein C, slow-type is a protein that in humans is encoded by the MYBPC1 gene.Myosin-binding protein C (MYBPC) is a myosin-associated protein of unknown function found in the cross-bridge-bearing zone, or C region, of A bands in striated muscle. Using a cDNA clone encoding the fast-type isoform of chicken MYBPC, Weber et al. (1993) screened a human fetal muscle cDNA library and isolated clones encoding the full-length human fast-type isoform of MYBPC. The cDNA for the fast type encodes a polypeptide of 1,142 amino acids with an expected molecular mass of 128 kD. They also isolated the slow-type isoform of human MYBPC (MYBPC1) and fully sequenced it.By study of somatic cell hybrids, Weber et al. (1993) mapped the gene for the slow type of myosin-binding protein C to human chromosome 12.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin Binding Protein C, Slow Type (MYBPC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin Binding Protein C, Slow Type (MYBPC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin Binding Protein C, Slow Type (MYBPC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin Binding Protein C, Slow Type (MYBPC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin Binding Protein C, Slow Type (MYBPC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD413Mu01 Recombinant Myosin Binding Protein C, Slow Type (MYBPC1) Positive Control; Immunogen; SDS-PAGE; WB.
RPD413Mu02 Recombinant Myosin Binding Protein C, Slow Type (MYBPC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD413Mu01 Polyclonal Antibody to Myosin Binding Protein C, Slow Type (MYBPC1) WB; IHC; ICC; IP.
PAD413Mu02 Polyclonal Antibody to Myosin Binding Protein C, Slow Type (MYBPC1) WB; IHC; ICC; IP.
Assay Kits SED413Mu ELISA Kit for Myosin Binding Protein C, Slow Type (MYBPC1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCD413Mu CLIA Kit for Myosin Binding Protein C, Slow Type (MYBPC1) Chemiluminescent immunoassay for Antigen Detection.
  1. "Mammalian skeletal muscle C-protein: purification from bovine muscle, binding to titin and the characterization of a full-length human cDNA."J. Cell Sci. 102:769-778(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment."Eur. J. Biochem. 216:661-669(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins."Cell. Mol. Life Sci. 63:723-734(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Autosomal recessive lethal congenital contractural syndrome type 4 (LCCS4) caused by a mutation in MYBPC1."Hum. Mutat. 33:1435-1438(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of the first and third Ig-like domain of myosin-binding protein C, slow-type."Submitted (JUN-2006) to the PDB data bank
  10. "Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1."Hum. Mol. Genet. 19:1165-1173(2010) [PubMed] [Europe PMC] [Abstract]