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Mitogen Activated Protein Kinase 12 (MAPK12)

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ERK6; PRKM12; p38 Gamma; SAPK3; Stress-activated protein kinase 3; Extracellular signal-regulated kinase 6; Mitogen-activated protein kinase p38 gamma

Mitogen Activated Protein Kinase 12 (MAPK12)
CCC D577
HGNC 6874
MGI 1353438
PubMed 8920915
RGD 70975
UniProt P53778
Wiki MAPK12
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.By screening with sequences based on those of the rat ERK3 gene, Lechner et al. (1996) isolated an ERK6 clone from a human skeletal muscle cDNA library. They reported that ERK6 appears to function as a signal transducer during differentiation of myoblasts to myotubes. Li et al. (1996) stated that SAPK3 is probably identical to the ERK6 gene cloned by Lechner et al. (1996).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD577Hu01 Recombinant Mitogen Activated Protein Kinase 12 (MAPK12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD577Hu01 Polyclonal Antibody to Mitogen Activated Protein Kinase 12 (MAPK12) WB; IHC
MAD577Hu21 Monoclonal Antibody to Mitogen Activated Protein Kinase 12 (MAPK12) WB; IHC; ICC; IP.
Assay Kits SED577Hu ELISA Kit for Mitogen Activated Protein Kinase 12 (MAPK12) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 12 (MAPK12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase 12 (MAPK12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase 12 (MAPK12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 12 (MAPK12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 12 (MAPK12) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 12 (MAPK12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase 12 (MAPK12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase 12 (MAPK12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 12 (MAPK12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 12 (MAPK12) ELISA Kit Customized Service Offer
  1. "ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation."Proc. Natl. Acad. Sci. U.S.A. 93:4355-4359(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization."Genomics 41:501-502(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The primary structure of p38 gamma: a new member of p38 group of MAP kinases."Biochem. Biophys. Res. Commun. 228:334-340(1996) [PubMed] [Europe PMC] [Abstract]
  4. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6."J. Biol. Chem. 273:1741-1748(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition."J. Biol. Chem. 274:12626-12631(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength."J. Biol. Chem. 275:40641-40648(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest."Mol. Cell. Biol. 20:4543-4552(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3)."J. Mol. Cell. Cardiol. 34:413-426(2002) [PubMed] [Europe PMC] [Abstract]
  12. "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria."Biochem. J. 367:577-585(2002) [PubMed] [Europe PMC] [Abstract]
  13. "p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle."Am. J. Physiol. 286:R342-R349(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Active mutants of the human p38alpha mitogen-activated protein kinase."J. Biol. Chem. 279:47040-47049(2004) [PubMed] [Europe PMC] [Abstract]
  15. "p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response."J. Biol. Chem. 282:31398-31408(2007) [PubMed] [Europe PMC] [Abstract]
  16. "p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock."J. Cell Sci. 123:2596-2604(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death."J. Cell Sci. 124:216-227(2011) [PubMed] [Europe PMC] [Abstract]
  19. "p38gamma mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer."Neoplasia 13:472-482(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Mechanisms and functions of p38 MAPK signalling."Biochem. J. 429:403-417(2010) [PubMed] [Europe PMC] [Abstract]
  21. "The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation."Structure 7:1057-1065(1999) [PubMed] [Europe PMC] [Abstract]
  22. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]