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ATP Binding Cassette Transporter C2 (ABCC2)

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CMOAT1; ABC30; CMOAT; DJS; MRP2; cMRP; Canalicular Multispecific Organic Anion transporter 1; Canalicular multidrug resistance protein; Multidrug resistance-associated 2

ATP Binding Cassette Transporter C2 (ABCC2)
CCC D622
HGNC 53
MGI 1352447
PubMed 20082599
RGD 2366
UniProt Q92887
Wiki ABCC2
ABCC2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).his protein is a member of the MRP subfamily, which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells.Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD622Hu01 Recombinant ATP Binding Cassette Transporter C2 (ABCC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD622Hu01 Polyclonal Antibody to ATP Binding Cassette Transporter C2 (ABCC2) WB; IHC
MAD622Hu21 Monoclonal Antibody to ATP Binding Cassette Transporter C2 (ABCC2) WB; IHC; ICC; IP.
Assay Kits SED622Hu ELISA Kit for ATP Binding Cassette Transporter C2 (ABCC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter C2 (ABCC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter C2 (ABCC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter C2 (ABCC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter C2 (ABCC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter C2 (ABCC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter C2 (ABCC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter C2 (ABCC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter C2 (ABCC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter C2 (ABCC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter C2 (ABCC2) ELISA Kit Customized Service Offer
  1. "A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation."Cancer Res. 56:4124-4129(1996) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats."J. Biol. Chem. 271:15091-15098(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome."Gastroenterology 117:653-660(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Hepatic secretion of conjugated drugs and endogenous substances."Semin. Liver Dis. 20:265-272(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity."J. Biol. Chem. 276:38108-38114(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome."Hum. Mol. Genet. 7:203-207(1998) [PubMed] [Europe PMC] [Abstract]
  14. "Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome."Am. J. Hum. Genet. 64:739-746(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome."Hepatology 32:1317-1328(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome."J. Biol. Chem. 276:36923-36930(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects."Pharmacogenetics 11:175-184(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells."Hum. Mutat. 33:750-762(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Neonatal Dubin-Johnson syndrome: novel compound heterozygous mutation in the ABCC2 gene."Pediatr. Int. 56:E62-E62(2014) [PubMed] [Europe PMC] [Abstract]