Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)

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THIL; ACAT; T2; MAT; Acetoacetyl Coenzyme A Thiolase

Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)
ACAT1 is a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.The 427-amino acid precursor had a molecular mass of 45.2 kD. The sequence included a 33-residue leader peptide and a 394-amino acid subunit of the mature enzyme, which had a molecular mass of 41.4 kD. In all 4 cell lines, the T2 mRNA had the same 1.7-kb transcript as that of the control; however, content was reduced in 2 cell lines and normal in the other 2. Human T2 is a homotetramer of 41-kD subunits.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD664Hu01Recombinant Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)SDS-PAGE; WB; ELISA; IP.
Antibodiesn/aMonoclonal Antibody to Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)CLIA Kit Customized Service Offer
n/aELISA Kit for Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD664Mu01Recombinant Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)SDS-PAGE; WB; ELISA; IP.
RPD664Mu02Recombinant Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD664Mu01Polyclonal Antibody to Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)WB, ICC, IHC-P, IHC-F, ELISA
PAD664Mu02Polyclonal Antibody to Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSED664MuELISA Kit for Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)Enzyme-linked immunosorbent assay

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)CLIA Kit Customized Service Offer
n/aELISA Kit for Acetyl Coenzyme A Acetyltransferase 1 (ACAT1)ELISA Kit Customized Service Offer
  1. "Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-ketothiolase deficiency."J. Clin. Invest. 86:2086-2092(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and expression of the human mitochondrial acetoacetyl-CoA thiolase-encoding gene."Gene 109:285-290(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]