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Regulator Of G Protein Signaling 6 (RGS6)

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GAP; S914

Regulator Of G Protein Signaling 6 (RGS6)
CCC D706
HGNC 10002
MGI 1354730
PubMed 24318880
RGD 3569
UniProt P49758
Wiki RGS6
Members of the RGS (regulator of G protein signaling) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.
RGS6, The predicted 472-amino acid protein has a calculated molecular mass of 54.4 kD. It contains an N-terminal dishevelled /egl10/pleckstrin (DEP) domain, a central G protein gamma subunit (GNG2)-like (GGL) domain, and an RGS domain near the C terminus. The variants encode proteins with long or short N-terminal domains, complete or incomplete GGL domains, 7 distinct C-terminal domains, and a common internal domain that includes the RGS domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD706Hu01 Recombinant Regulator Of G Protein Signaling 6 (RGS6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Regulator Of G Protein Signaling 6 (RGS6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of G Protein Signaling 6 (RGS6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of G Protein Signaling 6 (RGS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of G Protein Signaling 6 (RGS6) Recombinant Protein Customized Service Offer
Antibodies PAD706Mu01 Polyclonal Antibody to Regulator Of G Protein Signaling 6 (RGS6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Regulator Of G Protein Signaling 6 (RGS6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD706Ra01 Recombinant Regulator Of G Protein Signaling 6 (RGS6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD706Ra01 Polyclonal Antibody to Regulator Of G Protein Signaling 6 (RGS6) WB; IHC; ICC; IP.
MAD706Ra21 Monoclonal Antibody to Regulator Of G Protein Signaling 6 (RGS6) WB; IHC; ICC; IP.
Assay Kits SED706Ra ELISA Kit for Regulator Of G Protein Signaling 6 (RGS6) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants."J. Biol. Chem. 278:30261-30271(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11."Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways."J. Biol. Chem. 274:31087-31093(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease." Nature 375:754-760(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits."Proc. Natl. Acad. Sci. U.S.A. 105:6457-6462(2008) [PubMed] [Europe PMC] [Abstract]