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Glutathione Synthetase (GSS)

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Glutathione synthase

Glutathione Synthetase (GSS)
CCC D757
HGNC 4624
MGI 95852
PubMed 15990954
RGD 2752
UniProt P48637
Wiki GSS
Glutathione synthetase (EC 6.3.2.3) is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine, to form glutathione.
Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD757Hu01 Recombinant Glutathione Synthetase (GSS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD757Hu01 Polyclonal Antibody to Glutathione Synthetase (GSS) WB; IHC; ICC; IP.
MAD757Hu21 Monoclonal Antibody to Glutathione Synthetase (GSS) WB; IHC; ICC; IP.
Assay Kits SED757Hu ELISA Kit for Glutathione Synthetase (GSS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD757Mu01 Recombinant Glutathione Synthetase (GSS) Positive Control; Immunogen; SDS-PAGE; WB.
RPD757Mu02 Recombinant Glutathione Synthetase (GSS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD757Mu01 Polyclonal Antibody to Glutathione Synthetase (GSS) WB; IHC; ICC; IP.
PAD757Mu02 Polyclonal Antibody to Glutathione Synthetase (GSS) WB; IHC; ICC; IP.
Assay Kits SED757Mu ELISA Kit for Glutathione Synthetase (GSS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD757Ra01 Recombinant Glutathione Synthetase (GSS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD757Ra01 Polyclonal Antibody to Glutathione Synthetase (GSS) WB; IHC; ICC; IP.
MAD757Ra21 Monoclonal Antibody to Glutathione Synthetase (GSS) WB; IHC; ICC; IP.
Assay Kits SED757Ra ELISA Kit for Glutathione Synthetase (GSS) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Sequencing and expression of a cDNA for human glutathione synthetase."Biochem. J. 310:353-358(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative RNA splicing in expression of the glutathione synthetase gene in human cells."Mol. Biol. Rep. 37:2105-2109(2010) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]