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Kynureninase (KYNU)

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L-Kynurenine Hydrolase

Kynureninase (KYNU)
CCC D762
HGNC 6469
MGI 1918039
PubMed 9628740
RGD 71061
UniProt Q16719
Wiki Kynureninase
Kynureninase is a PLP dependent enzyme that catalyses the cleavage of Kyn into Ant. It can also act on 3hKyn (to produce 3hAnt) and some other (3-arylcarbonyl)-alanines.KYNU is part of the pathways for the catabolism of Trp and the biosynthesis of NAD cofactors from Trp. In KYNU reaction, PLP facilitates Cβ-Cγ bond cleavage. The reaction follows the same steps as the transamination reaction but does not hydrolyze the tautomerized Schiff base. The proposed reaction mechanism involves an attack of an enzyme nucleophile on the carbonyl carbon (Cγ) of the tautomerized 3hKyn-PLP Schiff base. This is followed by Cβ-Cγ bond cleavage to generate an acyl-enzyme intermediate together with a tautomerized Ala-PLP adduct. Hydrolysis of the acyl-enzyme then yields 3hAnt.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD762Hu01 Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
EPD762Hu41 Eukaryotic Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
RPD762Hu02 Recombinant Kynureninase (KYNU) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD762Hu01 Polyclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
MAD762Hu21 Monoclonal Antibody to Kynureninase (KYNU) WB; IHC; ICC; IP.
Assay Kits SED762Hu ELISA Kit for Kynureninase (KYNU) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kynureninase (KYNU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kynureninase (KYNU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kynureninase (KYNU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kynureninase (KYNU) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kynureninase (KYNU) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kynureninase (KYNU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kynureninase (KYNU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kynureninase (KYNU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kynureninase (KYNU) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kynureninase (KYNU) ELISA Kit Customized Service Offer
  1. "Isolation and expression of a cDNA clone encoding human kynureninase."Eur. J. Biochem. 239:460-468(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and recombinant expression of rat and human kynureninase."FEBS Lett. 408:5-10(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Purification and biochemical characterization of some of the properties of recombinant human kynureninase."Eur. J. Biochem. 269:2069-2074(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of Homo sapiens kynureninase."Biochemistry 46:2735-2744(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase."J. Inherit. Metab. Dis. 30:248-255(2007) [PubMed] [Europe PMC] [Abstract]