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Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1)

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GFAT; GFA; •D-fructose-6-phosphate amidotransferase 1; Hexosephosphate aminotransferase 1; Glutamine-fructose-6-phosphate aminotransferase isomerizing 1

Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1)
CCC D865
HGNC 4241
MGI 95698
PubMed 23794683
RGD 1549703
UniProt Q06210
Wiki GFPT1
Glutamine:fructose-6-phosphate amidotransferase (GFAT) catalyzes the formation of glucosamine 6-phosphate and is the first and rate-limiting enzyme of the hexosamine biosynthetic pathway. GFAT controls the flux of glucose into the hexosamine pathway, and thus formation of hexosamine products, and is most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Expression of these cDNA in E. coli produced a protein of approximately 77 kD and increased GFAT activity 4.5-fold over endogenous bacterial levels. Recombinant.
GFAT1L protein possessed functional GFAT activities and biochemical characteristics similar to those of GFAT1. Previously, GFAT1 was considered a simplex enzyme.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD865Hu01 Recombinant Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD865Hu01 Polyclonal Antibody to Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) WB; IHC; ICC; IP.
Assay Kits SED865Hu ELISA Kit for Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutamine Fructose-6-Phosphate Transaminase 1 (GFPT1) ELISA Kit Customized Service Offer
  1. "Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase."J. Biol. Chem. 267:25208-25212(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A novel variant of glutamine:fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle."Diabetes 50:2419-2424(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structural analysis of human glutamine:fructose-6-phosphate amidotransferase, a key regulator in type 2 diabetes."FEBS Lett. 583:163-167(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Hexosamine biosynthetic pathway mutations cause neuromuscular transmission defect." Am. J. Hum. Genet. 88:162-172(2011) [PubMed] [Europe PMC] [Abstract]