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Peptidoglycan Recognition Protein 1 (PGLYRP1)

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PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L; Tumor Necrosis Factor Ligand Superfamily Member 3 Like; Peptidoglycan recognition protein short

Peptidoglycan Recognition Protein 1 (PGLYRP1)
CCC D937
HGNC 8904
MGI 1345092
PubMed 23420883
RGD 621429
UniProt O75594
Wiki PGLYRP1

  • Innate nonself immune recognition relies on structures common among invading microbes, a process termed pattern recognition. Peptidoglycan is a fundamental component of the bacterial cell wall and is thus a candidate for a pattern recognized by the immune system.

  • The deduced human PGLYRP protein has 196 amino acids. Both the human and mouse PGLYRP proteins share 43% sequence identity with the T. ni PGLYRP protein. Recombinant mouse Pglyrp protein expressed in insect cells possessed an affinity for peptidoglycan. Dot blot analysis of a number of human tissue mRNAs detected strong expression in bone marrow and weak expression in lung, kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, and fetal spleen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD937Hu01 Recombinant Peptidoglycan Recognition Protein 1 (PGLYRP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD937Hu01 Polyclonal Antibody to Peptidoglycan Recognition Protein 1 (PGLYRP1) WB,IHC
MAD937Hu21 Monoclonal Antibody to Peptidoglycan Recognition Protein 1 (PGLYRP1) WB; IHC; ICC; IP.
Assay Kits SED937Hu ELISA Kit for Peptidoglycan Recognition Protein 1 (PGLYRP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD937Mu01 Recombinant Peptidoglycan Recognition Protein 1 (PGLYRP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPD937Mu02 Recombinant Peptidoglycan Recognition Protein 1 (PGLYRP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD937Mu01 Polyclonal Antibody to Peptidoglycan Recognition Protein 1 (PGLYRP1) WB; IHC; ICC; IP.
PAD937Mu02 Polyclonal Antibody to Peptidoglycan Recognition Protein 1 (PGLYRP1) WB; IHC; ICC; IP.
Assay Kits SED937Mu ELISA Kit for Peptidoglycan Recognition Protein 1 (PGLYRP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD937Ra01 Recombinant Peptidoglycan Recognition Protein 1 (PGLYRP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD937Ra01 Polyclonal Antibody to Peptidoglycan Recognition Protein 1 (PGLYRP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Peptidoglycan Recognition Protein 1 (PGLYRP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidoglycan Recognition Protein 1 (PGLYRP1) ELISA Kit Customized Service Offer
  1. "A peptidoglycan recognition protein in innate immunity conserved from insects to humans."Proc. Natl. Acad. Sci. U.S.A. 95:10078-10082(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules."J. Biol. Chem. 276:34686-34694(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Peptidoglycan recognition proteins are a new class of human bactericidal proteins."J. Biol. Chem. 281:5895-5907(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution."J. Mol. Biol. 347:683-691(2005) [PubMed] [Europe PMC] [Abstract]