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Baculoviral IAP Repeat Containing Protein 2 (BIRC2)

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API1; HIAP2; Hiap-2; MIHB; RNF48; cIAP1; Inhibitor of apoptosis protein 2; NFR2-TRAF Signalling Complex Protein; Apoptosis Inhibitor 1

Baculoviral IAP Repeat Containing Protein 2 (BIRC2)
CCC E231
HGNC 590
MGI 1197009
PubMed 17934460
RGD 620690
UniProt Q13490
Wiki BIRC2
Baculoviral IAP Repeat Containing Protein 2 is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals.Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE231Hu01 Recombinant Baculoviral IAP Repeat Containing Protein 2 (BIRC2) Positive Control; Immunogen; SDS-PAGE; WB.
RPE231Hu02 Recombinant Baculoviral IAP Repeat Containing Protein 2 (BIRC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE231Hu01 Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 2 (BIRC2) WB; IHC; ICC; IP.
LAE231Hu81 FITC-Linked Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 2 (BIRC2) WB; IHC; ICC; IF.
LAE231Hu71 Biotin-Linked Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 2 (BIRC2) WB; IHC; ICC.
PAE231Hu02 Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 2 (BIRC2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Baculoviral IAP Repeat Containing Protein 2 (BIRC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Baculoviral IAP Repeat Containing Protein 2 (BIRC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Baculoviral IAP Repeat Containing Protein 2 (BIRC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Baculoviral IAP Repeat Containing Protein 2 (BIRC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 2 (BIRC2) Polyclonal Antibody Customized Service Offer
Assay Kits SEE231Mu ELISA Kit for Baculoviral IAP Repeat Containing Protein 2 (BIRC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Baculoviral IAP Repeat Containing Protein 2 (BIRC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Baculoviral IAP Repeat Containing Protein 2 (BIRC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 2 (BIRC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Baculoviral IAP Repeat Containing Protein 2 (BIRC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Baculoviral IAP Repeat Containing Protein 2 (BIRC2) ELISA Kit Customized Service Offer
  1. "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins."Cell 83:1243-1252(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes."Nature 379:349-353(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors."Proc. Natl. Acad. Sci. U.S.A. 93:4974-4978(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "cIAP1 Localizes to the nuclear compartment and modulates the cell cycle."Cancer Res. 65:210-218(2005) [PubMed] [Europe PMC] [Abstract]
  8. "c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1."Mol. Cell 28:914-922(2007) [PubMed] [Europe PMC] [Abstract]
  9. "IAPs: more than just inhibitors of apoptosis proteins."Cell Cycle 7:1036-1046(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death."Curr. Opin. Cell Biol. 22:872-881(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases."Mol. Cell 40:810-822(2010) [PubMed] [Europe PMC] [Abstract]
  14. "IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer."Nat. Rev. Cancer 10:561-574(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity."Discov. Med. 11:221-231(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription."J. Biol. Chem. 286:26406-26417(2011) [PubMed] [Europe PMC] [Abstract]
  17. "The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2."J. Biol. Chem. 286:35380-35387(2011) [PubMed] [Europe PMC] [Abstract]
  18. "cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)."PLoS ONE 6:E22356-E22356(2011) [PubMed] [Europe PMC] [Abstract]
  19. "IAPs: guardians of RIPK1."Cell Death Differ. 19:58-66(2012) [PubMed] [Europe PMC] [Abstract]
  20. "IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex."Cell Rep. 3:724-733(2013) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat."Nat. Struct. Biol. 6:648-651(1999) [PubMed] [Europe PMC] [Abstract]
  22. "The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9."Acta Crystallogr. D 65:58-66(2009) [PubMed] [Europe PMC] [Abstract]
  23. "CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration."Mol. Cell 42:569-583(2011) [PubMed] [Europe PMC] [Abstract]