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Baculoviral IAP Repeat Containing Protein 3 (BIRC3)

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AIP1; API2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49; Apoptosis Inhibitor 2; TNFR2-TRAF Signaling Complex Protein; Mammalian IAP Homolog C; Inhibitor Of Apoptosis Protein 1

Baculoviral IAP Repeat Containing Protein 3 (BIRC3)
CCC E232
HGNC 591
MGI 1197007
PubMed 22308293
RGD 621282
UniProt Q13489
Wiki BIRC3
cIAP2 is a member of the Inhibitor of Apoptosis family that inhibit apoptosis by interfering with the activation of caspases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The cIAP2 protein contains three BIR domains, a UBA domain, a CARD domain and a RING finger domain. Transcript variants encoding the same isoform have been identified.
Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE232Hu01 Recombinant Baculoviral IAP Repeat Containing Protein 3 (BIRC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE232Hu01 Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 3 (BIRC3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Baculoviral IAP Repeat Containing Protein 3 (BIRC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Baculoviral IAP Repeat Containing Protein 3 (BIRC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Baculoviral IAP Repeat Containing Protein 3 (BIRC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Baculoviral IAP Repeat Containing Protein 3 (BIRC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 3 (BIRC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Baculoviral IAP Repeat Containing Protein 3 (BIRC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Baculoviral IAP Repeat Containing Protein 3 (BIRC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Baculoviral IAP Repeat Containing Protein 3 (BIRC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Baculoviral IAP Repeat Containing Protein 3 (BIRC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 3 (BIRC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Baculoviral IAP Repeat Containing Protein 3 (BIRC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Baculoviral IAP Repeat Containing Protein 3 (BIRC3) ELISA Kit Customized Service Offer
  1. "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins."Cell 83:1243-1252(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes."Nature 379:349-353(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors."Proc. Natl. Acad. Sci. U.S.A. 93:4974-4978(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes."Blood 93:3418-3431(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type."Genes Chromosomes Cancer 29:281-291(2000) [PubMed] [Europe PMC] [Abstract]
  7. "cIAP1 Localizes to the nuclear compartment and modulates the cell cycle."Cancer Res. 65:210-218(2005) [PubMed] [Europe PMC] [Abstract]
  8. "IAPs: more than just inhibitors of apoptosis proteins."Cell Cycle 7:1036-1046(2008) [PubMed] [Europe PMC] [Abstract]
  9. "To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death."Curr. Opin. Cell Biol. 22:872-881(2010) [PubMed] [Europe PMC] [Abstract]
  10. "IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer."Nat. Rev. Cancer 10:561-574(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity."Discov. Med. 11:221-231(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2."J. Biol. Chem. 286:35380-35387(2011) [PubMed] [Europe PMC] [Abstract]
  13. "cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)."PLoS ONE 6:E22356-E22356(2011) [PubMed] [Europe PMC] [Abstract]
  14. "IAPs: guardians of RIPK1."Cell Death Differ. 19:58-66(2012) [PubMed] [Europe PMC] [Abstract]
  15. "IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex."Cell Rep. 3:724-733(2013) [PubMed] [Europe PMC] [Abstract]